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- W136199187 abstract "The comparative localization properties of 5 radiopharmaceuticals which have been used to image primary brain tumors were investigated in a transplanted gliosarcoma in the Fisher 344 rat. Planar and SPECT images using pinhole collimation were used to investigate localization 2-4 times between 13d and 28d after transplant Imaging studies of intravenously administered Tl-201 Cl, Tc-99m-HMPAO, -MIBI, and -DTPA, and I-123 IMT were made in 70 rats. Localization properties were measured in unirradiated (n=39) and irradiated (n=31, 22.5 Gy to brain, 14 days after transplant) control and tumor-bearing rats. Ex vivo imaging and well cup measurements were made at sacrifice. MRI was used to define tumor border ROIs. Major observations include: (1) Tl, IMT, DTPA, and MIBI show increased uptake in tumor, with tumor-to-nontumor uptake ratios (tnt) from planar pinhole ROIs ranging from 1.3{plus_minus}.1 to 2.9{plus_minus}.7 between 13 and 28 d after transplant; HMPAO shows decreased activity in tumor with tnt ranging from 0.4-0.6{plus_minus}.1; (2) high resolution SPECT provides significantly greater discrimination between tumor and nontumor uptake: SPECT tnt=10.3{plus_minus}2{sub DTPA}, 3.0{plus_minus}.3{sub IMT}, 10.5{plus_minus}2{sub MIBI}, 5.6{plus_minus}2{sub TL} and 0.4{plus_minus}.1{sub HMPAO}; planar tnt=2.2{plus_minus}.4{sub DTPA}, 1.4{plus_minus}.1{sub IMT}, 1.9{plus_minus}.4{sub MIBI}, 2.1{plus_minus}.7{sub TL}, and 0.5{plus_minus}.1{sub HMPAO}; and (3) no significant differences in uptake are seen betweenmore » irradiated, more slowly growing tumors and the unirradiated tumors, and maximum tnt contrast is observed at 21 d with all radiopharmaceuticals. The study shows Tc-99m DTPA and Tc-99m MIBI to have the highest selective uptake in irradiated and unirradiated growing tumor.« less" @default.
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- W136199187 date "1994-05-01" @default.
- W136199187 modified "2023-09-27" @default.
- W136199187 title "Tracer localization in intracerebral gliosarcoma" @default.
- W136199187 hasPublicationYear "1994" @default.
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