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• W136240103 abstract "All physiological systems have complex interactions— both intrinsic and with external systems. Sepsis is an archetypal example of a self-regulating complex system, with multiple cascading non-linear interactions and feedbacks, acting in series and in parallel, to form a “scale-free” network. The process of sepsis may be modelled in terms of complexity theory as an iterative progression from a stable, homeostatic pathway or attractor to an unstable attractor of immunological dissonance and death. Given the convolutions of the septic attractor, complexity theory neatly explains why so many “magic bullet” therapies for sepsis have failed when given alone, since reductionist approaches which test individual treatments one at a time are highly unlikely to be effective in isolation. A new methodology of synchronously testing multiple therapies needs to be developed." @default.
• W136240103 created "2016-06-24" @default.
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• W136240103 creator A5040681773 @default.
• W136240103 date "2003-08-01" @default.
• W136240103 modified "2023-10-15" @default.
• W136240103 title "Chaotic Sepsis and the Magic Bullet" @default.
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• W136240103 doi "https://doi.org/10.1177/0310057x0303100414" @default.
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