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• W136304328 abstract "De novo synthesis of RNA sequences corresponding to intervening as well as to structural sequences of the ovalbumin gene have been detected in isolated oviduct nuclei. Their presence in the nuclear transcripts and their time course of induction support the hypothesis that transcription of structural and intervening sequences of the natural ovalbumin gene are regulated by steroid hormones. These results are in agreement with out previous demonstration of high-molecular-weight species of ovalbumin RNA in nuclei that contain structural as well as intervening RNA sequences and are thus likely precursors to mature cytoplasmic mRNAov. Analysis of the size of in vivo nuclear RNA by gel electrophoresis under denaturing conditions, revealed that withdrawal of hormone depletes the level of high molecular weight ovalbumin RNA as well as that of nature mRNAov and that readministration of estrogen induces the accumulation of both species. These results are consistent also with transcriptional regulation of the ovalbumin gene. In addition, they rule out the possibility that the rapid accumulation of mature mRNAov after secondard stimulation results from processing of ovalbumin RNA precursors that might have been stored in the withdrawn oviduct. We conclude that steroid hormones exert a primary effect at the level of gene transcription. Following this event, a series of coordinated cellular responses may occur which involve RNA processing, mRNA transport to the cytoplasm, protein synthesis and mRNA degradation. The final consequence of this network of molecular reactions is the induced cellular function inherent to a specific steroid hormone." @default.
• W136304328 created "2016-06-24" @default.
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• W136304328 date "1979-01-01" @default.
• W136304328 modified "2023-09-26" @default.
• W136304328 title "The Ovalbumin Gene: Transcriptional Regulation by Estrogen" @default.
• W136304328 cites W1724739629 @default.
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• W136304328 doi "https://doi.org/10.1007/978-1-4757-6589-2_25" @default.
• W136304328 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/474290" @default.
• W136304328 hasPublicationYear "1979" @default.
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