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• W136362144 startingPage "345" @default.
• W136362144 abstract "Although complex circuit reconstruction in the brain or spinal cord still presents many formidable challenges (1), an extensive body of embryonic central nervous system (CNS) transplantation research has established a compelling proof of principle for cell replacement therapies in animal models of Parkinson’ s disease (PD) (2) and other intractable neurological disorders (3,4). With the advent of stem/progenitor cell biology, focus has shifted from primary fetal CNS tissue to alternative cell sources, and many of these options offer promise for therapeutic neuronal replacement in the brain and spinal cord. The interest this has generated also has contributed to a greater focus on the progression toward clinical trials within the academic and commercial biotechnology sectors, as well as among patient advocacy groups. However, despite exciting recent advances, many intersecting scientific issues and principles of translational bench-to-bedside neurobiology remain to be resolved before the high expectations of stem or progenitor-cell-based therapies can be fully realized." @default.
• W136362144 created "2016-06-24" @default.
• W136362144 creator A5012651685 @default.
• W136362144 creator A5021394368 @default.
• W136362144 creator A5065852445 @default.
• W136362144 creator A5078454883 @default.
• W136362144 date "2003-01-01" @default.
• W136362144 modified "2023-09-26" @default.
• W136362144 title "Studies of a Human Neuron-Like Cell Line in Stroke and Spinal Cord Injury" @default.
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