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- W13638708 abstract "The intrinsic genetic instability of cancer cells makes age-related cancers more difficult to postpone or treat than any other age-related diseases. Any treatment that a cancer can resist by activating or inactivating specific genes is unlikely to succeed over the long term, because pre-existing cancer cells with the necessary gene expression pattern will withstand the therapy and proliferate. Whole-body Interdiction of Lengthening of Telomeres (WILT) is a proposal to pre-empt this problem by deleting from as many of our cells as possible the genes needed for telomere elongation. Cancers lacking these genes can never reach a life-threatening stage by altering gene expression, only by acquiring new genes, which is far more unlikely. Continuously-renewing tissues can be maintained by periodic reseeding with telomere elongation-incompetent stem cells that have had their telomeres lengthened in vitro with exogenous telomerase. Here, I describe why WILT might prove to be an exceptionally powerful anti-cancer modality." @default.
- W13638708 created "2016-06-24" @default.
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- W13638708 date "2005-01-01" @default.
- W13638708 modified "2023-10-17" @default.
- W13638708 title "Whole-body interdiction of lengthening of telomeres: a proposal for cancer prevention" @default.
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- W13638708 doi "https://doi.org/10.2741/1707" @default.
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