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- W136494306 abstract "The anatomical distribution of isotope-labeled compounds in cat brain has been studied. The isotope distribution was documented by radioautographs of brain slices, and by dissection of approximately 16 brain areas with subsequent homogenization, plating, and counting in an open window gas flow Geiger counter. The following compounds were studded: C/sup14/-isonicotinic acid hydrazide; S/sup 35/-carbon disulfide; C/suyp 14-urea; S/sup 35/acetazolamide; C/sup 14/ phenobarbital;S/sup 35/-thiopental; and cerebral blood vessels, is an indicator of brain vascularity). We are able to conclude that in all of the above compounds, the quantitative distribution pattern follow the anatomical boundaries within brain tissue. Furthermore, although there are general similarities in the concentration of some substances to the magnitude of blood supply of various regions of brain, the correlation is prominent inconsistencies. Each substance studied demonstrates some relatetively unique features in the pattern. For example, the relative concentration of isonicotinic acid hydrazide in hippocampus is much greater than the relative vascularity of this structure and increases while other areas of the brain are decreasing. Carbon disulifide (administered by inhalation) produces a pattern of radioautographic density comparable to a myelin stain, while thiopental, another fat soluble agent, produces a similar pattern at one plus hours, but at five minutssmore » after intravenous injection, the greater concentrations are found in gray matter. Acetozolamide is unusual in that early and quantitatively greatest entry into nervous tissue is by way of diffusion from cerebrospinal fluid, while blood to brain transport is quantitatively less. In addition, hippocampus, caudate nculeus, high concentration of acetazolamide longer than othr areas. These observations of indificual peculiarities of drug distribution provide clues for further study of the more funduamental physiolgic and biochemcial mechanisms involved in mediating such differences. Despite the essential interest in the differences mentioned above, in most remaining anatomical units of brain there is an over-all similarity in the pattern of many substances such as urea, isonicotinic acid hydrazide, phenobarbital, and acetazolamide. This would implay the operation of a common factor. It is possible that a study of regional difference in water compartments of brain may explain this common pattern. This investigational approach to the nervous system is regarded as a method by which drugs and other subetences are used as indicatiors of physiologic and biochemical processes in focal anatomical units of brain. We do not assume that the deomonof action. (auth)« less" @default.
- W136494306 created "2016-06-24" @default.
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- W136494306 date "1958-10-31" @default.
- W136494306 modified "2023-09-27" @default.
- W136494306 title "OBSERVATIONS ON ISOTOPE LABELED DRUGS IN THE CENTRAL NERVOUS SYSTEM" @default.
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