Matches in SemOpenAlex for { <https://semopenalex.org/work/W136606487> ?p ?o ?g. }
Showing items 1 to 87 of
87
with 100 items per page.
- W136606487 abstract "The parathyroid hormone 2 receptor (PTH2R) is a G protein coupled receptor. Pharmacological and anatomical evidence suggests that the recently identified tuberoinfundibular peptide of 39 residues is, and parathyroid hormone and parathyroid hormone-related peptide are not, its endogenous ligand. Initial functional studies suggest that the PTH2R is involved in the regulation of viscerosensory information processing. As a first step towards clinical applications, herein we describe the presence of the PTH2R in the human brainstem.Total RNA was isolated from postmortem human cortical and brainstem samples for RT-PCR. Good quality RNA, as assessed on formaldehyde gel, was reverse transcribed. The combined cDNA products were used as template in PCR reactions with primer pairs specific for the human PTH2R. In addition, PTH2R immunolabelling was performed on free floating sections of the human medulla oblongata using fluorescent amplification immunochemistry.Specific bands in the RT-PCR experiments and sequencing of PCR products demonstrated the expression of PTH2R mRNA in the human brainstem. A high density of PTH2R-immunoreactive fibers was found in brain regions of the medulla oblongata including the nucleus of the solitary tract, the spinal trigeminal nucleus, and the dorsal reticular nucleus of the medulla.Independent demonstration of the presence of PTH2R mRNA and immunoreactivity supports the specific expression of the PTH2R in the human brainstem. The distribution of PTH2R-immunoreactive fibers in viscerosensory brain regions is similar to that reported in mouse and rat suggesting a similar role of the PTH2R in human as in rodents. This finding will have important implications when experimental data obtained on the function of the TIP39-PTH2R neuromodulator system in rodents are to be utilized in human." @default.
- W136606487 created "2016-06-24" @default.
- W136606487 creator A5003436188 @default.
- W136606487 creator A5020875533 @default.
- W136606487 creator A5060835610 @default.
- W136606487 creator A5073787062 @default.
- W136606487 creator A5080258851 @default.
- W136606487 date "2008-03-30" @default.
- W136606487 modified "2023-09-23" @default.
- W136606487 title "Evidence for the expression of parathyroid hormone 2 receptor in the human brainstem." @default.
- W136606487 cites W1495437191 @default.
- W136606487 cites W1966591888 @default.
- W136606487 cites W1969080702 @default.
- W136606487 cites W2051159177 @default.
- W136606487 cites W2053904152 @default.
- W136606487 cites W2079025995 @default.
- W136606487 cites W2091705541 @default.
- W136606487 cites W2131524297 @default.
- W136606487 cites W2146799127 @default.
- W136606487 cites W2171165948 @default.
- W136606487 cites W2915137691 @default.
- W136606487 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2716013" @default.
- W136606487 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/18459453" @default.
- W136606487 hasPublicationYear "2008" @default.
- W136606487 type Work @default.
- W136606487 sameAs 136606487 @default.
- W136606487 citedByCount "2" @default.
- W136606487 countsByYear W1366064872023 @default.
- W136606487 crossrefType "journal-article" @default.
- W136606487 hasAuthorship W136606487A5003436188 @default.
- W136606487 hasAuthorship W136606487A5020875533 @default.
- W136606487 hasAuthorship W136606487A5060835610 @default.
- W136606487 hasAuthorship W136606487A5073787062 @default.
- W136606487 hasAuthorship W136606487A5080258851 @default.
- W136606487 hasConcept C126322002 @default.
- W136606487 hasConcept C134018914 @default.
- W136606487 hasConcept C135285700 @default.
- W136606487 hasConcept C16613235 @default.
- W136606487 hasConcept C170493617 @default.
- W136606487 hasConcept C174510640 @default.
- W136606487 hasConcept C2781208988 @default.
- W136606487 hasConcept C519063684 @default.
- W136606487 hasConcept C551621295 @default.
- W136606487 hasConcept C71315377 @default.
- W136606487 hasConcept C71924100 @default.
- W136606487 hasConcept C86803240 @default.
- W136606487 hasConcept C98274493 @default.
- W136606487 hasConceptScore W136606487C126322002 @default.
- W136606487 hasConceptScore W136606487C134018914 @default.
- W136606487 hasConceptScore W136606487C135285700 @default.
- W136606487 hasConceptScore W136606487C16613235 @default.
- W136606487 hasConceptScore W136606487C170493617 @default.
- W136606487 hasConceptScore W136606487C174510640 @default.
- W136606487 hasConceptScore W136606487C2781208988 @default.
- W136606487 hasConceptScore W136606487C519063684 @default.
- W136606487 hasConceptScore W136606487C551621295 @default.
- W136606487 hasConceptScore W136606487C71315377 @default.
- W136606487 hasConceptScore W136606487C71924100 @default.
- W136606487 hasConceptScore W136606487C86803240 @default.
- W136606487 hasConceptScore W136606487C98274493 @default.
- W136606487 hasLocation W1366064871 @default.
- W136606487 hasOpenAccess W136606487 @default.
- W136606487 hasPrimaryLocation W1366064871 @default.
- W136606487 hasRelatedWork W1883275440 @default.
- W136606487 hasRelatedWork W1975214384 @default.
- W136606487 hasRelatedWork W1984986047 @default.
- W136606487 hasRelatedWork W1991556400 @default.
- W136606487 hasRelatedWork W2003878642 @default.
- W136606487 hasRelatedWork W2008778656 @default.
- W136606487 hasRelatedWork W2012252708 @default.
- W136606487 hasRelatedWork W2022764813 @default.
- W136606487 hasRelatedWork W2024143337 @default.
- W136606487 hasRelatedWork W2037705925 @default.
- W136606487 hasRelatedWork W2046102646 @default.
- W136606487 hasRelatedWork W2047075155 @default.
- W136606487 hasRelatedWork W2064226918 @default.
- W136606487 hasRelatedWork W2078958345 @default.
- W136606487 hasRelatedWork W2102179607 @default.
- W136606487 hasRelatedWork W2127808815 @default.
- W136606487 hasRelatedWork W2131558518 @default.
- W136606487 hasRelatedWork W2149674790 @default.
- W136606487 hasRelatedWork W2163484532 @default.
- W136606487 hasRelatedWork W2392879155 @default.
- W136606487 isParatext "false" @default.
- W136606487 isRetracted "false" @default.
- W136606487 magId "136606487" @default.
- W136606487 workType "article" @default.