Matches in SemOpenAlex for { <https://semopenalex.org/work/W136793352> ?p ?o ?g. }
- W136793352 endingPage "178" @default.
- W136793352 startingPage "157" @default.
- W136793352 abstract "A unique aspect of ionizing radiation as a therapeutic tool is the locoregional application of the cytotoxic therapy without systemic toxicity. However, there are several limitations to the efficacy of radiation treatment: ionizing radiation is mainly effective for the treatment of cancers that have not spread. Furthermore, in patients presenting with locoregional disease, some are cured whereas in others disease recurs and progresses either locally and/or systemically. Some tumors are controlled with high probability by low doses of radiation (e.g., seminomas, lymphomas), others are controlled by moderate to high radiation doses (e.g., breast and prostate adenocarcinomas) and still others will progress even after treatment with high radiation doses, exceeding normal tissue tolerance (e.g., glioblastoma, melanoma). The reason for failure to cure may include treatment-related factors (e.g., metastases out of treatment volume, large volume, unfavorable location) or tumor-related factors (e.g., radiation-resistant tumor cells, limited tolerance of the surrounding normal tissue, hypoxic tumor cells) (Jung and Dritschilo 1996). Research for improvement of radiotherapy focuses on physical and biological aspects: with the improvement of radiation technology (e.g., intensity-modulated radiation therapy [IMRT]) and the introduction of novel imaging techniques (e.g., PET), the control of treatment-related factors has increased. Modern radiobiology focuses on the modulation of molecular processes, thereby overcoming inherent radiation resistance of the tumor cell." @default.
- W136793352 created "2016-06-24" @default.
- W136793352 creator A5009887943 @default.
- W136793352 creator A5044990086 @default.
- W136793352 creator A5049984560 @default.
- W136793352 date "2003-01-01" @default.
- W136793352 modified "2023-09-23" @default.
- W136793352 title "Role of Signaling Pathway Modification" @default.
- W136793352 cites W1497251274 @default.
- W136793352 cites W1500729563 @default.
- W136793352 cites W1515564094 @default.
- W136793352 cites W1604468403 @default.
- W136793352 cites W167077950 @default.
- W136793352 cites W172276776 @default.
- W136793352 cites W1752089945 @default.
- W136793352 cites W178871068 @default.
- W136793352 cites W1919155696 @default.
- W136793352 cites W1967006634 @default.
- W136793352 cites W1969158591 @default.
- W136793352 cites W1972751666 @default.
- W136793352 cites W1972910961 @default.
- W136793352 cites W1976837232 @default.
- W136793352 cites W1977187758 @default.
- W136793352 cites W1977323980 @default.
- W136793352 cites W1978228534 @default.
- W136793352 cites W1978469465 @default.
- W136793352 cites W1980083933 @default.
- W136793352 cites W1980891354 @default.
- W136793352 cites W1982961932 @default.
- W136793352 cites W1983999811 @default.
- W136793352 cites W1988221004 @default.
- W136793352 cites W1990613904 @default.
- W136793352 cites W1993597367 @default.
- W136793352 cites W2000098053 @default.
- W136793352 cites W2004199183 @default.
- W136793352 cites W2005284058 @default.
- W136793352 cites W2007010211 @default.
- W136793352 cites W2008676708 @default.
- W136793352 cites W2013609629 @default.
- W136793352 cites W2020600496 @default.
- W136793352 cites W2021759592 @default.
- W136793352 cites W2021875656 @default.
- W136793352 cites W2022307219 @default.
- W136793352 cites W2022342238 @default.
- W136793352 cites W2025198554 @default.
- W136793352 cites W2026522253 @default.
- W136793352 cites W2032361307 @default.
- W136793352 cites W2034269086 @default.
- W136793352 cites W2034317592 @default.
- W136793352 cites W2035904165 @default.
- W136793352 cites W2038593531 @default.
- W136793352 cites W2039231974 @default.
- W136793352 cites W2043066069 @default.
- W136793352 cites W2044351980 @default.
- W136793352 cites W2044416896 @default.
- W136793352 cites W2048997359 @default.
- W136793352 cites W2049108649 @default.
- W136793352 cites W2050119840 @default.
- W136793352 cites W2054395348 @default.
- W136793352 cites W2055349083 @default.
- W136793352 cites W2055889594 @default.
- W136793352 cites W2057949133 @default.
- W136793352 cites W2059221693 @default.
- W136793352 cites W2060618478 @default.
- W136793352 cites W2064047613 @default.
- W136793352 cites W2067162187 @default.
- W136793352 cites W2067751798 @default.
- W136793352 cites W2068449224 @default.
- W136793352 cites W2068912983 @default.
- W136793352 cites W2070075260 @default.
- W136793352 cites W2074540590 @default.
- W136793352 cites W2075338210 @default.
- W136793352 cites W2077561395 @default.
- W136793352 cites W2077754831 @default.
- W136793352 cites W2078581194 @default.
- W136793352 cites W2078928513 @default.
- W136793352 cites W2079571554 @default.
- W136793352 cites W2081894694 @default.
- W136793352 cites W2085114776 @default.
- W136793352 cites W2086199722 @default.
- W136793352 cites W2086753528 @default.
- W136793352 cites W2088868608 @default.
- W136793352 cites W2088896055 @default.
- W136793352 cites W2090495131 @default.
- W136793352 cites W2099000660 @default.
- W136793352 cites W2100937050 @default.
- W136793352 cites W2101680441 @default.
- W136793352 cites W2103119722 @default.
- W136793352 cites W2104398672 @default.
- W136793352 cites W2110184627 @default.
- W136793352 cites W2111273332 @default.
- W136793352 cites W2113092282 @default.
- W136793352 cites W2118393528 @default.
- W136793352 cites W2118560029 @default.
- W136793352 cites W2118692187 @default.
- W136793352 cites W2121779634 @default.
- W136793352 cites W2122961418 @default.
- W136793352 cites W2132000251 @default.