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• W136992488 abstract "To investigate whether Z:ZCLA Mongolian gerbils are readily susceptible to infection by human hepatitis E virus (HEV).Z:ZCLA Mongolian gerbils were infected with a clinical HEV strain isolated from an acute hepatitis E patient, and virus pathogenesis was assessed in this host. Non-infected gerbils served as the control group. Feces samples from gerbils were collected weekly for reverse transcription-nested polymerase chain reaction. Serum anti-HEV IgG and alanine aminotransferase (ALT) were detected by enzyme linked immunosorbent assay. At sacrifice, each animal's liver, spleen and kidney were collected for histopathologic examination.HEV-infected gerbils showed fatigue, with histopathological changes observed in the liver, spleen and kidney. HEV RNA was detected in fecal samples taken at day 7 after inoculation and the detectable levels lasted out to day 42 after inoculation. Interestingly, ALT levels were only moderately increased in the HEV-infected animals compared with the non-infected control group.Z:ZCLA Mongolian gerbils are susceptible to human HEV." @default.
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• W136992488 date "2015-01-01" @default.
• W136992488 modified "2023-09-30" @default.
• W136992488 title "Experimental infection of Z:ZCLA Mongolian gerbils with human hepatitis E virus" @default.
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• W136992488 doi "https://doi.org/10.3748/wjg.v21.i3.862" @default.
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