Matches in SemOpenAlex for { <https://semopenalex.org/work/W137015340> ?p ?o ?g. }
Showing items 1 to 89 of
89
with 100 items per page.
- W137015340 endingPage "100" @default.
- W137015340 startingPage "93" @default.
- W137015340 abstract "Two different methods, a rosette assay and a direct binding assay, have been employed in an examination of the binding of human IgG1 to mouse macrophages. In both cases, inhibition of IgG binding was demonstrated by Fc (CH2 + CH3 domains) and pFc' (CH3 domains) fragments of human IgG. In a homologous system, the binding of 125I-human IgG to human peripheral-blood monocytes was inhibited by the Fc fragment whereas the pFc' fragment was inactive. Scatchard plot analysis of the binding data from both the heterologous and homologous systems allowed association constants and numbers of receptors per cell to be calculated. A more thorough examination of the possible location of IgG Fc-receptor binding sites was made using less orthodox proteolytic cleavage fragments of IgG. The site on human IgG1 responsible for binding to mouse macrophage Fc receptors was confirmed to be within the CH3 domains. Human IgG1 binding to homologous monocytes was shown, using a dimeric C gamma 2 domain fragment, to be via the CH2 domains, and was dependent on the integrity of the covalent interaction between the C gamma 2 domains at the hinge region." @default.
- W137015340 created "2016-06-24" @default.
- W137015340 creator A5007305042 @default.
- W137015340 creator A5081779167 @default.
- W137015340 date "1983-09-01" @default.
- W137015340 modified "2023-10-18" @default.
- W137015340 title "The localization of the binding site(s) on human IgG1 for the Fc receptors on homologous monocytes and heterologous mouse macrophages." @default.
- W137015340 cites W11307706 @default.
- W137015340 cites W121958947 @default.
- W137015340 cites W141475715 @default.
- W137015340 cites W1532082174 @default.
- W137015340 cites W1536056048 @default.
- W137015340 cites W1570938380 @default.
- W137015340 cites W1626256461 @default.
- W137015340 cites W1893651774 @default.
- W137015340 cites W1913891236 @default.
- W137015340 cites W1947473800 @default.
- W137015340 cites W2017245432 @default.
- W137015340 cites W2025274557 @default.
- W137015340 cites W2033759384 @default.
- W137015340 cites W2069322347 @default.
- W137015340 cites W2086695584 @default.
- W137015340 cites W2091405344 @default.
- W137015340 cites W2092638671 @default.
- W137015340 cites W2093944259 @default.
- W137015340 cites W2143785893 @default.
- W137015340 cites W2300200268 @default.
- W137015340 cites W2408960955 @default.
- W137015340 cites W2418672961 @default.
- W137015340 cites W4290108838 @default.
- W137015340 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/1454235" @default.
- W137015340 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/6885113" @default.
- W137015340 hasPublicationYear "1983" @default.
- W137015340 type Work @default.
- W137015340 sameAs 137015340 @default.
- W137015340 citedByCount "5" @default.
- W137015340 countsByYear W1370153402012 @default.
- W137015340 crossrefType "journal-article" @default.
- W137015340 hasAuthorship W137015340A5007305042 @default.
- W137015340 hasAuthorship W137015340A5081779167 @default.
- W137015340 hasConcept C104317684 @default.
- W137015340 hasConcept C107824862 @default.
- W137015340 hasConcept C125823703 @default.
- W137015340 hasConcept C153911025 @default.
- W137015340 hasConcept C159654299 @default.
- W137015340 hasConcept C170493617 @default.
- W137015340 hasConcept C185592680 @default.
- W137015340 hasConcept C203014093 @default.
- W137015340 hasConcept C2780115692 @default.
- W137015340 hasConcept C2780898057 @default.
- W137015340 hasConcept C2909900342 @default.
- W137015340 hasConcept C55493867 @default.
- W137015340 hasConcept C64894306 @default.
- W137015340 hasConcept C86803240 @default.
- W137015340 hasConceptScore W137015340C104317684 @default.
- W137015340 hasConceptScore W137015340C107824862 @default.
- W137015340 hasConceptScore W137015340C125823703 @default.
- W137015340 hasConceptScore W137015340C153911025 @default.
- W137015340 hasConceptScore W137015340C159654299 @default.
- W137015340 hasConceptScore W137015340C170493617 @default.
- W137015340 hasConceptScore W137015340C185592680 @default.
- W137015340 hasConceptScore W137015340C203014093 @default.
- W137015340 hasConceptScore W137015340C2780115692 @default.
- W137015340 hasConceptScore W137015340C2780898057 @default.
- W137015340 hasConceptScore W137015340C2909900342 @default.
- W137015340 hasConceptScore W137015340C55493867 @default.
- W137015340 hasConceptScore W137015340C64894306 @default.
- W137015340 hasConceptScore W137015340C86803240 @default.
- W137015340 hasIssue "1" @default.
- W137015340 hasLocation W1370153401 @default.
- W137015340 hasOpenAccess W137015340 @default.
- W137015340 hasPrimaryLocation W1370153401 @default.
- W137015340 hasRelatedWork W137015340 @default.
- W137015340 hasRelatedWork W1529809181 @default.
- W137015340 hasRelatedWork W1532403879 @default.
- W137015340 hasRelatedWork W1878676843 @default.
- W137015340 hasRelatedWork W2024250706 @default.
- W137015340 hasRelatedWork W2025274557 @default.
- W137015340 hasRelatedWork W2093944259 @default.
- W137015340 hasRelatedWork W2143785893 @default.
- W137015340 hasRelatedWork W2419130295 @default.
- W137015340 hasRelatedWork W2611690321 @default.
- W137015340 hasVolume "50" @default.
- W137015340 isParatext "false" @default.
- W137015340 isRetracted "false" @default.
- W137015340 magId "137015340" @default.
- W137015340 workType "article" @default.