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• W137019919 abstract "Thymidylate synthase (TS) is a folate-dependent enzyme that catalyzes the reductive methylation of 2′-deoxyuridine-5′-monophosphate (dUMP) by the reduced folate 5, 10methylenetetrahydrofolate (CH2-THF) to 2′-deoxythymidine-5 ′-monophosphate (dTMP, thymidylate) and dihydrofolate (1,2). Once synthesized, dTMP is then metabolized intracellularly to the dTTP triphosphate form, an essential precursor for DNA biosynthesis (see Fig. 1). Whereas dTMP can also be formed through the salvage pathway via phosphorylation of thymidine by thymidine kinase, the TS-catalyzed reaction provides the sole intracellular de novo source of dTMP. Given its central role in dTMP and DNA biosynthesis and given the observation that inhibition of this reaction results in cessation of cellular proliferation and growth, TS represents an important target for cancer chemotherapy (2–4)." @default.
• W137019919 created "2016-06-24" @default.
• W137019919 creator A5006142010 @default.
• W137019919 creator A5043633584 @default.
• W137019919 creator A5083512608 @default.
• W137019919 date "1999-01-01" @default.
• W137019919 modified "2023-09-22" @default.
• W137019919 title "Molecular Regulation of Expression of Thymidylate Synthase" @default.
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• W137019919 doi "https://doi.org/10.1007/978-1-59259-725-3_19" @default.
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