FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W13709414> ?p ?o ?g. }

• W13709414 abstract "ABSTRACT Introduction: Renal transplant recipients (RTR) with abnormal glucose tolerance (AGT) are at an increased risk of graft failure and cardiovascular disease (CVD). CVD is the major cause of death in RTR. Whilst there are numerous known risk factors for AGT in RTR, it is unknown whether lifestyle factors are found in the presence or play a role in the development of AGT in RTR. The nutritional status of RTR in an Australian population has also not been extensively investigated. Investigation into these areas could help identify modifiable areas for change in the RTR population. Multidisciplinary lifestyle modification, including diet and physical activity (PA) advice from a dietitian, may help reduce modifiable risk factors for CVD in RTR with AGT. Aims: The principle aims of this thesis are to; 1) assess the incidence of obesity and central obesity in RTR and compare to rates in the general Australian population, 2) investigate and compare modifiable lifestyle factors and adipokine levels in RTR with AGT and normal glucose tolerance (NGT) and 3) investigate the effect of a multidisciplinary lifestyle intervention (including dietetic advice) on modifiable CVD risk factors in RTR with AGT. Methods: Chapter 1 presents a review of the literature describing the main nutritional challenges in RTR, cardiovascular risk factors in RTR including adipokine profiles and the role of body composition, diet and PA in RTR. Chapter 2 details the clinical, biochemical, nutritional, body composition, PA and statistical methodologies used in this thesis. In Chapter 3 a descriptive analysis of the anthropometry and cardiovascular risk profile of RTR in an Australian setting is investigated. Chapter 4 investigates the nutritional status of RTR with NGT and AGT in more detail, assessing diet, PA, adipokines and body composition. In Chapter 5, the current literature on lifestyle intervention management (including nutritional management) for obesity and type 2 diabetes mellitus in the general population is discussed. Building on previous chapters, Chapter 6 investigates the effect of a multi-disciplinary lifestyle intervention (with dietetic input) on modifiable cardiovascular risk factors in RTR with AGT. Results: In Chapter 3 it was found that RTR are significantly more centrally obese than those in the general population, and this was particularly the case in younger RTR. Central obesity was associated with CVD risk factors in RTR. Chapter 4 found that a lower level of PA, obesity and central obesity are associated with AGT in RTR, whereas no difference in adipokines or dietary intake was found. In Chapter 6, multidisciplinary lifestyle intervention with dietetic input was found to improve certain risk factors for CVD in RTR with AGT, such as dietary factors (total fat and saturated fat intake) and lipid levels. Conclusions: Central obesity is a common problem in RTR, particularly in those with AGT. Higher levels of PA are associated with lower risk of AGT in RTR, and may help reduce the incidence of central obesity in RTR. Multidisciplinary lifestyle intervention, with dietetic input, can improve some modifiable CVD risk factors in RTR with AGT, however more intensive intervention is required to significantly reduce the incidence of obesity. Key Words: Renal Transplant; Abnormal Glucose Tolerance, Obesity; Cardiovascular Disease; Physical Activity Australian and New Zealand Standard Research Classifications (ANZSRC) 1111 Nutrition and Dietetics, 1102 Cardiovascular medicine and Haematology, 1199 Other Medicine and Health Sciences" @default.
• W13709414 created "2016-06-24" @default.
• W13709414 creator A5063288120 @default.
• W13709414 date "2008-11-01" @default.
• W13709414 modified "2023-09-27" @default.
• W13709414 title "Assessment of Lifestyle and Metabolic Factors in Renal Transplant Recipients" @default.
• W13709414 hasPublicationYear "2008" @default.
• W13709414 type Work @default.
• W13709414 sameAs 13709414 @default.
• W13709414 citedByCount "0" @default.
• W13709414 crossrefType "journal-article" @default.
• W13709414 hasAuthorship W13709414A5063288120 @default.
• W13709414 hasConcept C120665830 @default.
• W13709414 hasConcept C121332964 @default.
• W13709414 hasConcept C126322002 @default.
• W13709414 hasConcept C194832188 @default.
• W13709414 hasConcept C2779134260 @default.
• W13709414 hasConcept C2780613262 @default.
• W13709414 hasConcept C2908647359 @default.
• W13709414 hasConcept C511355011 @default.
• W13709414 hasConcept C61511704 @default.
• W13709414 hasConcept C71924100 @default.
• W13709414 hasConcept C74909509 @default.
• W13709414 hasConcept C99454951 @default.
• W13709414 hasConceptScore W13709414C120665830 @default.
• W13709414 hasConceptScore W13709414C121332964 @default.
• W13709414 hasConceptScore W13709414C126322002 @default.
• W13709414 hasConceptScore W13709414C194832188 @default.
• W13709414 hasConceptScore W13709414C2779134260 @default.
• W13709414 hasConceptScore W13709414C2780613262 @default.
• W13709414 hasConceptScore W13709414C2908647359 @default.
• W13709414 hasConceptScore W13709414C511355011 @default.
• W13709414 hasConceptScore W13709414C61511704 @default.
• W13709414 hasConceptScore W13709414C71924100 @default.
• W13709414 hasConceptScore W13709414C74909509 @default.
• W13709414 hasConceptScore W13709414C99454951 @default.
• W13709414 hasLocation W137094141 @default.
• W13709414 hasOpenAccess W13709414 @default.
• W13709414 hasPrimaryLocation W137094141 @default.
• W13709414 hasRelatedWork W1514388039 @default.
• W13709414 hasRelatedWork W1996645842 @default.
• W13709414 hasRelatedWork W1998409085 @default.
• W13709414 hasRelatedWork W2002247421 @default.
• W13709414 hasRelatedWork W2068738115 @default.
• W13709414 hasRelatedWork W2080568064 @default.
• W13709414 hasRelatedWork W2131285955 @default.
• W13709414 hasRelatedWork W2162655989 @default.
• W13709414 hasRelatedWork W2310838725 @default.
• W13709414 hasRelatedWork W2321864984 @default.
• W13709414 hasRelatedWork W2488896803 @default.
• W13709414 hasRelatedWork W2969144714 @default.
• W13709414 hasRelatedWork W3046943833 @default.
• W13709414 hasRelatedWork W3109729553 @default.
• W13709414 hasRelatedWork W3173855984 @default.
• W13709414 hasRelatedWork W3195397288 @default.
• W13709414 hasRelatedWork W3197988099 @default.
• W13709414 hasRelatedWork W63811915 @default.
• W13709414 hasRelatedWork W98519832 @default.
• W13709414 hasRelatedWork W2179723090 @default.
• W13709414 isParatext "false" @default.
• W13709414 isRetracted "false" @default.
• W13709414 magId "13709414" @default.
• W13709414 workType "article" @default.