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• W137116573 abstract "Research Article1 January 1989free access N-myc is frequently activated by proviral insertion in MuLV-induced T cell lymphomas. M. van Lohuizen M. van Lohuizen Division of Molecular Genetics, Netherlands Cancer Institute, Amsterdam. Search for more papers by this author M. Breuer M. Breuer Division of Molecular Genetics, Netherlands Cancer Institute, Amsterdam. Search for more papers by this author A. Berns A. Berns Division of Molecular Genetics, Netherlands Cancer Institute, Amsterdam. Search for more papers by this author M. van Lohuizen M. van Lohuizen Division of Molecular Genetics, Netherlands Cancer Institute, Amsterdam. Search for more papers by this author M. Breuer M. Breuer Division of Molecular Genetics, Netherlands Cancer Institute, Amsterdam. Search for more papers by this author A. Berns A. Berns Division of Molecular Genetics, Netherlands Cancer Institute, Amsterdam. Search for more papers by this author Author Information M. Lohuizen1, M. Breuer1 and A. Berns1 1Division of Molecular Genetics, Netherlands Cancer Institute, Amsterdam. The EMBO Journal (1989)8:133-136https://doi.org/10.1002/j.1460-2075.1989.tb03357.x PDFDownload PDF of article text and main figures. ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinked InMendeleyWechatReddit Figures & Info We report a new common proviral insertion site in murine leukemia virus-induced T cell lymphomas to be N-myc. Proviral activation of N-myc was found in 35% of independently induced primary tumors. The vast majority of the proviral insertions occur within a small segment of the 3′-untranslated region of the N-myc gene, directly downstream of the protein-encoding domain. This results in an increased level of expression of a truncated N-myc mRNA. Together with the previously shown c-myc activation we now find involvement of myc genes in greater than 75% of the primary T cell lymphomas induced by Moloney murine leukemia virus in C57BL10 and BALB/c mice, and show for the first time that N-myc can be over-expressed by a mechanism other than gene amplification. Previous ArticleNext Article Volume 8Issue 11 January 1989In this issue RelatedDetailsLoading ..." @default.
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• W137116573 title "N-myc is frequently activated by proviral insertion in MuLV-induced T cell lymphomas." @default.
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• W137116573 doi "https://doi.org/10.1002/j.1460-2075.1989.tb03357.x" @default.
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