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• W13712814 startingPage "275" @default.
• W13712814 abstract "As a tetramer, acetylcholinesterase (AChE) is anchored to the basal lamina of the neuromuscular junction and to the membrane of neuronal synapses. We have previously shown that collagen Q (ColQ) anchors AChE at the neuromuscular junction. We have now cloned the gene PRiMA (proline-rich membrane anchor) encoding the AChE anchor in mammalian brain. We show that PRiMA is able to organize AChE into tetramers and to anchor them at the surface of transfected cells. Furthermore, we demonstrate that AChE is actually anchored in neural cell membranes through its interaction with PRiMA. Finally, we propose that only PRiMA anchors AChE in mammalian brain and muscle cell membranes." @default.
• W13712814 created "2016-06-24" @default.
• W13712814 creator A5045848833 @default.
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• W13712814 date "2002-01-01" @default.
• W13712814 modified "2023-10-09" @default.
• W13712814 title "PRiMA" @default.
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• W13712814 doi "https://doi.org/10.1016/s0896-6273(01)00584-0" @default.
• W13712814 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/11804574" @default.
• W13712814 hasPublicationYear "2002" @default.
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