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- W137155657 abstract "Stimulation of intact islets with D-glucose, the major insulin secretagogue, or with carbachol, a muscarinic agonist, results in the accumulation of inositoltrisphosphate (IP/sub 3/) suggesting that activation of phospholipase C (PLC) has a major role in stimulus-secretion coupling. Carbachol activation of PLC is an example of receptor-mediated activation in islets, whereas, the mechanism of glucose activation of PLC is controversial since a glucose receptor has not been identified. They have measured PLC activity in digitonin-permeabilized islets. Islets were labeled with /sup 3/H-inositol, permeabilized and IP/sub 3/ accumulation measured by HPLC. Carbachol, in the presence of ATP, GTP and 1 ..mu..M free Ca/sup 2 +/ released two-fold more Ins 1,3,4-P/sub 3/ than control in a time-dependent manner. Glucose, under the same conditions also significantly released more Ins 1,3,4-P/sub 3/ than control. This effect was not due to metabolism of glucose nor to an effect on the IP/sub 3/-phosphomonoesterase. Preliminary Ca/sup 2 +/-dependency studies indicate that PLC is not activated by Ca/sup 2 +/ in the submicromolar range. In conclusion, these studies show that Ca/sup 2 +/ does not activate PLC, and furthermore, that D-glucose may be recognized directly by PLC." @default.
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- W137155657 date "1987-05-01" @default.
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- W137155657 title "Glucose and carbachol activate phospholipase C in digitonin-permeabilized islets" @default.
- W137155657 hasPublicationYear "1987" @default.
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