Matches in SemOpenAlex for { <https://semopenalex.org/work/W137168614> ?p ?o ?g. }
- W137168614 endingPage "2061" @default.
- W137168614 startingPage "2053" @default.
- W137168614 abstract "beta-Hydroxyaspartic acid is a post-translationally modified amino acid found in a number of plasma proteins in a domain homologous to epidermal growth factor. Its presence can be correlated with a high affinity Ca2+ binding site, with a dissociation constant of 10-100 microM. We describe a system for the expression of human coagulation factor IX in dog kidney cells in tissue culture, in which the post-translational modifications and the biochemical activity are indistinguishable from factor IX synthesized in vivo. This system has been used to express eight different point mutations of human factor IX in the first epidermal growth factor domain in order to study the role of beta-hydroxyaspartate at residue 64, and the adjacent carboxylate residues at positions 47, 49 and 78. We conclude that this domain is essential for factor IX function and suggest that Ca2+ binds to carboxylate ions in this domain and stabilizes a conformation necessary for the interaction of factor IXa with factor X, factor VIII and phospholipid in the next step of the clotting cascade." @default.
- W137168614 created "2016-06-24" @default.
- W137168614 creator A5020805128 @default.
- W137168614 creator A5024707141 @default.
- W137168614 creator A5032832140 @default.
- W137168614 creator A5043604322 @default.
- W137168614 creator A5061413790 @default.
- W137168614 creator A5080169008 @default.
- W137168614 creator A5085911231 @default.
- W137168614 date "1988-07-01" @default.
- W137168614 modified "2023-10-16" @default.
- W137168614 title "The role of beta-hydroxyaspartate and adjacent carboxylate residues in the first EGF domain of human factor IX." @default.
- W137168614 cites W107781538 @default.
- W137168614 cites W1440850118 @default.
- W137168614 cites W1479925054 @default.
- W137168614 cites W1499326065 @default.
- W137168614 cites W1502744283 @default.
- W137168614 cites W1537891220 @default.
- W137168614 cites W1865475665 @default.
- W137168614 cites W1964253980 @default.
- W137168614 cites W1965376197 @default.
- W137168614 cites W1969051510 @default.
- W137168614 cites W1969631009 @default.
- W137168614 cites W1970066855 @default.
- W137168614 cites W1988808109 @default.
- W137168614 cites W1991298348 @default.
- W137168614 cites W1995441993 @default.
- W137168614 cites W1995828159 @default.
- W137168614 cites W1996383115 @default.
- W137168614 cites W1997016178 @default.
- W137168614 cites W2008443499 @default.
- W137168614 cites W2009836049 @default.
- W137168614 cites W2011507067 @default.
- W137168614 cites W2018462584 @default.
- W137168614 cites W2019130075 @default.
- W137168614 cites W2033994918 @default.
- W137168614 cites W2042748071 @default.
- W137168614 cites W2044134913 @default.
- W137168614 cites W2047420497 @default.
- W137168614 cites W2060013497 @default.
- W137168614 cites W2068793497 @default.
- W137168614 cites W2069958139 @default.
- W137168614 cites W2070560763 @default.
- W137168614 cites W2081945921 @default.
- W137168614 cites W2088189362 @default.
- W137168614 cites W2111800688 @default.
- W137168614 cites W2112503578 @default.
- W137168614 cites W2113564117 @default.
- W137168614 cites W2120097537 @default.
- W137168614 cites W2153417097 @default.
- W137168614 cites W215476265 @default.
- W137168614 cites W2201473605 @default.
- W137168614 cites W2226529940 @default.
- W137168614 cites W2396323037 @default.
- W137168614 cites W2463207153 @default.
- W137168614 cites W4251685699 @default.
- W137168614 cites W50743869 @default.
- W137168614 cites W5358143 @default.
- W137168614 cites W6932061 @default.
- W137168614 cites W87735197 @default.
- W137168614 cites W97897255 @default.
- W137168614 doi "https://doi.org/10.1002/j.1460-2075.1988.tb03045.x" @default.
- W137168614 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/454485" @default.
- W137168614 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/3262057" @default.
- W137168614 hasPublicationYear "1988" @default.
- W137168614 type Work @default.
- W137168614 sameAs 137168614 @default.
- W137168614 citedByCount "231" @default.
- W137168614 countsByYear W1371686142012 @default.
- W137168614 countsByYear W1371686142013 @default.
- W137168614 countsByYear W1371686142014 @default.
- W137168614 countsByYear W1371686142015 @default.
- W137168614 countsByYear W1371686142016 @default.
- W137168614 countsByYear W1371686142017 @default.
- W137168614 countsByYear W1371686142018 @default.
- W137168614 countsByYear W1371686142019 @default.
- W137168614 countsByYear W1371686142020 @default.
- W137168614 countsByYear W1371686142021 @default.
- W137168614 countsByYear W1371686142022 @default.
- W137168614 countsByYear W1371686142023 @default.
- W137168614 crossrefType "journal-article" @default.
- W137168614 hasAuthorship W137168614A5020805128 @default.
- W137168614 hasAuthorship W137168614A5024707141 @default.
- W137168614 hasAuthorship W137168614A5032832140 @default.
- W137168614 hasAuthorship W137168614A5043604322 @default.
- W137168614 hasAuthorship W137168614A5061413790 @default.
- W137168614 hasAuthorship W137168614A5080169008 @default.
- W137168614 hasAuthorship W137168614A5085911231 @default.
- W137168614 hasBestOaLocation W1371686141 @default.
- W137168614 hasConcept C107824862 @default.
- W137168614 hasConcept C126322002 @default.
- W137168614 hasConcept C153660203 @default.
- W137168614 hasConcept C170493617 @default.
- W137168614 hasConcept C203014093 @default.
- W137168614 hasConcept C25166345 @default.
- W137168614 hasConcept C2776362946 @default.
- W137168614 hasConcept C2777292125 @default.
- W137168614 hasConcept C2777444498 @default.