FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W137168656> ?p ?o ?g. }

• W137168656 endingPage "31" @default.
• W137168656 startingPage "126" @default.
• W137168656 abstract "Little is known about the interaction of novel anticancer drugs with other treatment modalities. THE AIM of this study was to examine the effect of combining imatinib mesylate (STI-571) with radiation or cisplatin on the survival of two human solid tumor cell lines - SKNMC cells derived from Ewing sarcoma and breast cancer MCF-7 cells.Cell proliferation was determined using the sulphorodamine B cytotoxicity assay. Cell cycle analysis was performed with flow cytometry. Apoptosis was determined using a commercial cell death ELISA plus kit. Phosphorylated AKT, which has been suggested to be involved in radiation resistance, was detected by Western blot analysis.Exposure of SKNMC cells to STI-571 resulted in a dose-dependent antiproliferative effect and a decrease in phosphorylated AKT expression. There was no evidence of apoptosis. The combination of STI-571 with radiation or cisplatin had an additive antiproliferative effect in SKNMC cells (60% reduction in cell number). A similar effect was observed in human MCF-7 breast cancer cells.STI-571 improves the outcome of cisplatin or irradiation treatment in vitro. AKT pathway may play a role in the additive effect of STI-571 and irradiation." @default.
• W137168656 created "2016-06-24" @default.
• W137168656 creator A5000168655 @default.
• W137168656 creator A5020388402 @default.
• W137168656 creator A5044094654 @default.
• W137168656 creator A5047295157 @default.
• W137168656 creator A5056816227 @default.
• W137168656 creator A5070158409 @default.
• W137168656 creator A5077891420 @default.
• W137168656 date "2007-06-01" @default.
• W137168656 modified "2023-09-26" @default.
• W137168656 title "Combined antiproliferative activity of imatinib mesylate (STI-571) with radiation or cisplatin in vitro." @default.
• W137168656 cites W1527449410 @default.
• W137168656 cites W1577995302 @default.
• W137168656 cites W1584553446 @default.
• W137168656 cites W1892856901 @default.
• W137168656 cites W1971980147 @default.
• W137168656 cites W1977450629 @default.
• W137168656 cites W1991198879 @default.
• W137168656 cites W2015015957 @default.
• W137168656 cites W2039045990 @default.
• W137168656 cites W2047067305 @default.
• W137168656 cites W2059320393 @default.
• W137168656 cites W2060975018 @default.
• W137168656 cites W2070557480 @default.
• W137168656 cites W2073526787 @default.
• W137168656 cites W2085249677 @default.
• W137168656 cites W2092462025 @default.
• W137168656 cites W2104800170 @default.
• W137168656 cites W2106997432 @default.
• W137168656 cites W2107733793 @default.
• W137168656 cites W2109689528 @default.
• W137168656 cites W2125649123 @default.
• W137168656 cites W2134615815 @default.
• W137168656 cites W2135594240 @default.
• W137168656 cites W2151493026 @default.
• W137168656 cites W2183423932 @default.
• W137168656 cites W2324850882 @default.
• W137168656 cites W2329648702 @default.
• W137168656 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/17704745" @default.
• W137168656 hasPublicationYear "2007" @default.
• W137168656 type Work @default.
• W137168656 sameAs 137168656 @default.
• W137168656 citedByCount "7" @default.
• W137168656 countsByYear W1371686562015 @default.
• W137168656 countsByYear W1371686562016 @default.
• W137168656 countsByYear W1371686562017 @default.
• W137168656 countsByYear W1371686562018 @default.
• W137168656 countsByYear W1371686562022 @default.
• W137168656 crossrefType "journal-article" @default.
• W137168656 hasAuthorship W137168656A5000168655 @default.
• W137168656 hasAuthorship W137168656A5020388402 @default.
• W137168656 hasAuthorship W137168656A5044094654 @default.
• W137168656 hasAuthorship W137168656A5047295157 @default.
• W137168656 hasAuthorship W137168656A5056816227 @default.
• W137168656 hasAuthorship W137168656A5070158409 @default.
• W137168656 hasAuthorship W137168656A5077891420 @default.
• W137168656 hasConcept C109316439 @default.
• W137168656 hasConcept C109541995 @default.
• W137168656 hasConcept C121608353 @default.
• W137168656 hasConcept C126322002 @default.
• W137168656 hasConcept C185592680 @default.
• W137168656 hasConcept C190283241 @default.
• W137168656 hasConcept C202751555 @default.
• W137168656 hasConcept C203014093 @default.
• W137168656 hasConcept C2776694085 @default.
• W137168656 hasConcept C2777583451 @default.
• W137168656 hasConcept C2778239845 @default.
• W137168656 hasConcept C2778729363 @default.
• W137168656 hasConcept C29537977 @default.
• W137168656 hasConcept C2994423619 @default.
• W137168656 hasConcept C3019892230 @default.
• W137168656 hasConcept C502942594 @default.
• W137168656 hasConcept C553184892 @default.
• W137168656 hasConcept C55493867 @default.
• W137168656 hasConcept C62112901 @default.
• W137168656 hasConcept C71924100 @default.
• W137168656 hasConcept C75217442 @default.
• W137168656 hasConcept C96232424 @default.
• W137168656 hasConcept C98274493 @default.
• W137168656 hasConceptScore W137168656C109316439 @default.
• W137168656 hasConceptScore W137168656C109541995 @default.
• W137168656 hasConceptScore W137168656C121608353 @default.
• W137168656 hasConceptScore W137168656C126322002 @default.
• W137168656 hasConceptScore W137168656C185592680 @default.
• W137168656 hasConceptScore W137168656C190283241 @default.
• W137168656 hasConceptScore W137168656C202751555 @default.
• W137168656 hasConceptScore W137168656C203014093 @default.
• W137168656 hasConceptScore W137168656C2776694085 @default.
• W137168656 hasConceptScore W137168656C2777583451 @default.
• W137168656 hasConceptScore W137168656C2778239845 @default.
• W137168656 hasConceptScore W137168656C2778729363 @default.
• W137168656 hasConceptScore W137168656C29537977 @default.
• W137168656 hasConceptScore W137168656C2994423619 @default.
• W137168656 hasConceptScore W137168656C3019892230 @default.
• W137168656 hasConceptScore W137168656C502942594 @default.
• W137168656 hasConceptScore W137168656C553184892 @default.
• W137168656 hasConceptScore W137168656C55493867 @default.

• next