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- W137179722 endingPage "356" @default.
- W137179722 startingPage "337" @default.
- W137179722 abstract "The prognosis for patients with malignant gliomas remains poor despite investigation of multiple novel therapies. Ongoing discovery of many of the genetic alterations associated with the transformed phenotype has permitted the development of new therapeutic approaches focused specifically on attacking these changes in neoplastic cells. Targeted therapies can be divided into three categories: (1) monoclonal antibodies (MAbs), (2) antisense oligonucleotides, and (3) small molecule drugs (SMDs). SMDs target growth factors and their receptors, downstream signaling signal transduction cascades, cell-cycle control molecules, and modulators of apopotosis, or invasion factors. This chapter focuses on the rationale for using small molecule targeted therapy for the treatment of malignant gliomas, and on progress made in the development of this class of drugs for clinical use. In the future, molecular profiling of gliomas will provide a basis for individualized “tailored therapy” using targeted molecules along with traditional cytotoxic therapies." @default.
- W137179722 created "2016-06-24" @default.
- W137179722 creator A5015824786 @default.
- W137179722 creator A5087808466 @default.
- W137179722 date "2007-11-20" @default.
- W137179722 modified "2023-09-25" @default.
- W137179722 title "Small Molecule Agents" @default.
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