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- W137187837 abstract "The organic nitrates are clearly the most effective agents for the treatment of acute ischemic episodes. However, due to the rapid development of tolerance to their hemodynamic and clinical effects, these agents cannot provide continuous antiischemic protection. A clear demonstration of tolerance development has been obtained with all forms of nitrate administration—intravenous, oral, ointment, or patch—and is dose dependent. Hemodynamic tolerance has been shown both in the pulmonary and systemic circulation, and implies a shorter duration of action and loss of a dose-response relationship. Those formulations that provide continuous nitrate exposure (such as nitroglycerin patches) have been shown to produce only a short period of antiischemic effect, as can be demonstrated by exercise testing. Since tolerance develops within a few hours of nitrate administration and is rapidly reversed following their withdrawal, clinical studies to show the development and reversal of tolerance need not be long in duration." @default.
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- W137187837 title "Experimental Evaluation and Clinical Relevance of Tolerance to Nitrates" @default.
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