FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W137188978> ?p ?o ?g. }

• W137188978 endingPage "R606" @default.
• W137188978 startingPage "R601" @default.
• W137188978 abstract "Transgenic mice lacking a functional myostatin (MSTN) gene demonstrate greater skeletal muscle mass resulting from muscle fiber hypertrophy and hyperplasia (McPherron, A. C., A. M. Lawler, and S.-J. Lee. Nature 387: 83–90, 1997). Therefore, we hypothesized that, in normal mice, MSTN may act as a negative regulator of muscle mass. Specifically, we hypothesized that the predominately slow (type I) soleus muscle, which demonstrates greater atrophy than the fast (type II) gastrocnemius-plantaris complex (Gast/PLT), would show more elevation in MSTN mRNA abundance during hindlimb unloading (HU). Surprisingly, MSTN mRNA was not detectable in weight-bearing or HU soleus muscle, which atrophied 42% by the 7th day of HU in female ICR mice. In contrast, MSTN mRNA was present in weight-bearing Gast/PLT muscle and was significantly elevated (67%) at 1 day but not at 3 or 7 days of HU. However, the Gast/PLT muscle had only atrophied 17% by the 7th day of HU. Because the soleus is composed only of type I and IIa fibers, whereas the Gast/PLT expresses type IId/x and IIb in addition to type I and IIa, it was necessary to perform a more careful analysis of the relationship between MSTN mRNA levels and myosin heavy-chain (MHC) isoform expression (as a marker of fiber type). A significant correlation ( r = 0.725, P < 0.0005) was noted between the percentage of MHC isoform IIb expression and MSTN mRNA abundance in several muscles of the mouse hindlimb. These results indicate that MSTN expression is not strongly associated with muscle atrophy induced by HU; however, it is strongly associated with MHC isoform IIb expression in normal muscle." @default.
• W137188978 created "2016-06-24" @default.
• W137188978 creator A5043284336 @default.
• W137188978 creator A5054357653 @default.
• W137188978 creator A5063382312 @default.
• W137188978 date "1999-08-01" @default.
• W137188978 modified "2023-10-13" @default.
• W137188978 title "Skeletal muscle myostatin mRNA expression is fiber-type specific and increases during hindlimb unloading" @default.
• W137188978 cites W132592907 @default.
• W137188978 cites W1498886216 @default.
• W137188978 cites W1925403794 @default.
• W137188978 cites W1936652120 @default.
• W137188978 cites W1991928981 @default.
• W137188978 cites W2025463260 @default.
• W137188978 cites W2038474589 @default.
• W137188978 cites W2053079324 @default.
• W137188978 cites W2054460914 @default.
• W137188978 cites W2068856136 @default.
• W137188978 cites W2069552078 @default.
• W137188978 cites W2107844605 @default.
• W137188978 cites W2130122556 @default.
• W137188978 cites W2145303230 @default.
• W137188978 cites W2158254766 @default.
• W137188978 cites W2162539094 @default.
• W137188978 cites W2165316503 @default.
• W137188978 cites W2165868509 @default.
• W137188978 cites W2175991112 @default.
• W137188978 cites W2187831830 @default.
• W137188978 cites W2256342783 @default.
• W137188978 cites W4294216491 @default.
• W137188978 doi "https://doi.org/10.1152/ajpregu.1999.277.2.r601" @default.
• W137188978 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/10444569" @default.
• W137188978 hasPublicationYear "1999" @default.
• W137188978 type Work @default.
• W137188978 sameAs 137188978 @default.
• W137188978 citedByCount "189" @default.
• W137188978 countsByYear W1371889782012 @default.
• W137188978 countsByYear W1371889782013 @default.
• W137188978 countsByYear W1371889782014 @default.
• W137188978 countsByYear W1371889782015 @default.
• W137188978 countsByYear W1371889782016 @default.
• W137188978 countsByYear W1371889782017 @default.
• W137188978 countsByYear W1371889782018 @default.
• W137188978 countsByYear W1371889782019 @default.
• W137188978 countsByYear W1371889782020 @default.
• W137188978 countsByYear W1371889782021 @default.
• W137188978 countsByYear W1371889782022 @default.
• W137188978 countsByYear W1371889782023 @default.
• W137188978 crossrefType "journal-article" @default.
• W137188978 hasAuthorship W137188978A5043284336 @default.
• W137188978 hasAuthorship W137188978A5054357653 @default.
• W137188978 hasAuthorship W137188978A5063382312 @default.
• W137188978 hasConcept C104317684 @default.
• W137188978 hasConcept C105580179 @default.
• W137188978 hasConcept C126322002 @default.
• W137188978 hasConcept C134018914 @default.
• W137188978 hasConcept C150194340 @default.
• W137188978 hasConcept C167414201 @default.
• W137188978 hasConcept C2776104385 @default.
• W137188978 hasConcept C2776214593 @default.
• W137188978 hasConcept C2776263037 @default.
• W137188978 hasConcept C2777488582 @default.
• W137188978 hasConcept C2778106681 @default.
• W137188978 hasConcept C2779959927 @default.
• W137188978 hasConcept C3763915 @default.
• W137188978 hasConcept C51738704 @default.
• W137188978 hasConcept C53345823 @default.
• W137188978 hasConcept C55493867 @default.
• W137188978 hasConcept C6997183 @default.
• W137188978 hasConcept C71924100 @default.
• W137188978 hasConcept C86803240 @default.
• W137188978 hasConcept C95444343 @default.
• W137188978 hasConcept C97816823 @default.
• W137188978 hasConceptScore W137188978C104317684 @default.
• W137188978 hasConceptScore W137188978C105580179 @default.
• W137188978 hasConceptScore W137188978C126322002 @default.
• W137188978 hasConceptScore W137188978C134018914 @default.
• W137188978 hasConceptScore W137188978C150194340 @default.
• W137188978 hasConceptScore W137188978C167414201 @default.
• W137188978 hasConceptScore W137188978C2776104385 @default.
• W137188978 hasConceptScore W137188978C2776214593 @default.
• W137188978 hasConceptScore W137188978C2776263037 @default.
• W137188978 hasConceptScore W137188978C2777488582 @default.
• W137188978 hasConceptScore W137188978C2778106681 @default.
• W137188978 hasConceptScore W137188978C2779959927 @default.
• W137188978 hasConceptScore W137188978C3763915 @default.
• W137188978 hasConceptScore W137188978C51738704 @default.
• W137188978 hasConceptScore W137188978C53345823 @default.
• W137188978 hasConceptScore W137188978C55493867 @default.
• W137188978 hasConceptScore W137188978C6997183 @default.
• W137188978 hasConceptScore W137188978C71924100 @default.
• W137188978 hasConceptScore W137188978C86803240 @default.
• W137188978 hasConceptScore W137188978C95444343 @default.
• W137188978 hasConceptScore W137188978C97816823 @default.
• W137188978 hasIssue "2" @default.
• W137188978 hasLocation W1371889781 @default.
• W137188978 hasLocation W1371889782 @default.
• W137188978 hasOpenAccess W137188978 @default.

• next