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- W137226304 abstract "The three-dimensional structure of the principal neurotoxin of the cobra, Naja naja siamensis, has been determined at 2.8 Å resolution. Crystals were grown by micro-dialysis of toxin solutions against a mixture (3:1) of 2-methyl-2,4-pentanediol and buffer (0.05 M glycine. HCl, pH 2.0). The hexagonal needles had the space group P6522 with unit cell dimensions a=b=74.59 Å, c=42.89 Å. Two heavy atom derivatives were prepared by cocrystallization. The polypeptide chain folds into three major loops and one tail emerging from a globular head. The protuding long central loop (residues 21-40) is flanked on either side by two shorter loops (residues 4-13 and 44-55); the C-terminal tail (residues 63-71) hangs behind this loop. The molecular conformation is determined by four disulfide bridges in the head and one at the tip of the long loop, by a triple standed β-pleated sheet involving the long loop, and by hydrophobic interactions stabilizing the other two loops." @default.
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- W137226304 date "1980-01-01" @default.
- W137226304 modified "2023-09-23" @default.
- W137226304 title "THREE-DIMENSIONAL STRUCTURE OF α-COBRATOXIN" @default.
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- W137226304 doi "https://doi.org/10.1016/b978-0-08-024952-0.50065-x" @default.
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