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- W137257584 abstract "Abstract Vitamin D receptor (VDR) KO mice are more susceptible to several different experimental models of inflammatory bowel disease (IBD) including the Rag KO transfer model when naïve VDR KO CD4 T cells are used to induce disease. CD8 T cells from WT mice do not induce IBD when transferred to Rag KO mice. Conversely, VDR KO CD8 T cells induce IBD in Rag KO recipients. There is no difference in the expression of CD62L, CD44, CCR9 and α4β7 or secretion of IFN-γ and TNF-α between WT and VDR KO CD8 T cells. Disease induced by VDR KO CD8 T cells is mild and the recipients do not lose weight or show outward signs of disease. Instead histological evidence of inflammation and increased numbers of CD8 T cells in the IEL characterize the disease. While WT CD8 T cells fail to induce IBD when transferred to Rag KO mice, they do induce a fulminating form of IBD when transferred to Rag/VDR double KO (DKO) mice. Therefore, the host expression of the VDR alters CD8 T cell development and or function. Experiments to probe the cause of CD8 T cell induced pathology in DKO mice are underway." @default.
- W137257584 created "2016-06-24" @default.
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- W137257584 date "2010-04-01" @default.
- W137257584 modified "2023-09-25" @default.
- W137257584 title "Vitamin D receptor deficiency alters the ability of CD8 T cells to induce inflammatory bowel disease. (135.14)" @default.
- W137257584 doi "https://doi.org/10.4049/jimmunol.184.supp.135.14" @default.
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