Matches in SemOpenAlex for { <https://semopenalex.org/work/W13726257> ?p ?o ?g. }
Showing items 1 to 74 of
74
with 100 items per page.
- W13726257 endingPage "55" @default.
- W13726257 startingPage "1141" @default.
- W13726257 abstract "Melatonin,N-acetyl-5-methoxytryptamine, is a hormonal product of the pineal gland. Its synthesis is higher at night than during the day in all vertebrates including man. Once melatonin is produced in the pineal gland it is quickly released into the vascular system. The rapid release of melatonin is generally believed to relate to its high lipophilicity which allows it to readily pass through the membrane of the pinealocytes and the endothelial cells which line the capillaries. The result of the nocturnal synthesis and secretion of melatonin is high blood levels at night. Also because of its highly lipophilic nature, melatonin from the blood readily escapes into every other bodily fluid and all cells in the body. Until recently it was generally thought that melatonin's action in the organism depended on its exclusive interaction with specific receptors on cells located in discrete locations. Certainly, the interactions of melatonin with these membrane-bound receptors are believed to mediate the endocrine and circadian rhythm effects of melatonin. It was recently discovered, however, that melatonin's primary action may not depend on the previously described membrane receptors. We have found that melatonin is a very potent hydroxyl radical scavenger; free radicals and the hydroxyl radical in particular, because of its very high reactivity, can be extremely damaging to macromolecules in cells. Compared to glutathione and mannitol, two well known free radical scavengers, melatonin is a more powerful scavenger and affords protection of molecules, especially DNA, from oxidative damage. Melatonin's extremely high diffusibility is important for its scavenging action because this feature allows it to enter all cells and every subcellular compartment. Whereas the free radical quenching activity of melatonin does not require a receptor, we also have evidence that it may be bound in the nucleus thereby providing on-site protection to DNA. Besides scavenging the highly toxic hydroxyl radical, melatonin also stimulates glutathione peroxidase activity which metabolizes the precursor of the hydroxyl radical, hydrogen peroxide, to water. Thus, melatonin has at least two means to protect the cell from oxidative damage, i.e., it breaks down hydrogen peroxide to harmless water and, in the event any hydroxyl radicals are formed, melatonin scavenges them. Melatonin may be the premier molecule to protect the organism from oxidative damage." @default.
- W13726257 created "2016-06-24" @default.
- W13726257 creator A5063159500 @default.
- W13726257 date "1993-11-01" @default.
- W13726257 modified "2023-10-18" @default.
- W13726257 title "Interactions of the pineal hormone melatonin with oxygen-centered free radicals: a brief review." @default.
- W13726257 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/8136717" @default.
- W13726257 hasPublicationYear "1993" @default.
- W13726257 type Work @default.
- W13726257 sameAs 13726257 @default.
- W13726257 citedByCount "31" @default.
- W13726257 countsByYear W137262572013 @default.
- W13726257 countsByYear W137262572014 @default.
- W13726257 countsByYear W137262572018 @default.
- W13726257 countsByYear W137262572020 @default.
- W13726257 countsByYear W137262572021 @default.
- W13726257 countsByYear W137262572023 @default.
- W13726257 crossrefType "journal-article" @default.
- W13726257 hasAuthorship W13726257A5063159500 @default.
- W13726257 hasConcept C126322002 @default.
- W13726257 hasConcept C134018914 @default.
- W13726257 hasConcept C170493617 @default.
- W13726257 hasConcept C185592680 @default.
- W13726257 hasConcept C202023056 @default.
- W13726257 hasConcept C2776151105 @default.
- W13726257 hasConcept C2778163477 @default.
- W13726257 hasConcept C2778182776 @default.
- W13726257 hasConcept C2780059843 @default.
- W13726257 hasConcept C2780072125 @default.
- W13726257 hasConcept C2781269140 @default.
- W13726257 hasConcept C2992339995 @default.
- W13726257 hasConcept C41443022 @default.
- W13726257 hasConcept C55493867 @default.
- W13726257 hasConcept C71315377 @default.
- W13726257 hasConcept C71924100 @default.
- W13726257 hasConcept C86803240 @default.
- W13726257 hasConceptScore W13726257C126322002 @default.
- W13726257 hasConceptScore W13726257C134018914 @default.
- W13726257 hasConceptScore W13726257C170493617 @default.
- W13726257 hasConceptScore W13726257C185592680 @default.
- W13726257 hasConceptScore W13726257C202023056 @default.
- W13726257 hasConceptScore W13726257C2776151105 @default.
- W13726257 hasConceptScore W13726257C2778163477 @default.
- W13726257 hasConceptScore W13726257C2778182776 @default.
- W13726257 hasConceptScore W13726257C2780059843 @default.
- W13726257 hasConceptScore W13726257C2780072125 @default.
- W13726257 hasConceptScore W13726257C2781269140 @default.
- W13726257 hasConceptScore W13726257C2992339995 @default.
- W13726257 hasConceptScore W13726257C41443022 @default.
- W13726257 hasConceptScore W13726257C55493867 @default.
- W13726257 hasConceptScore W13726257C71315377 @default.
- W13726257 hasConceptScore W13726257C71924100 @default.
- W13726257 hasConceptScore W13726257C86803240 @default.
- W13726257 hasIssue "11" @default.
- W13726257 hasLocation W137262571 @default.
- W13726257 hasOpenAccess W13726257 @default.
- W13726257 hasPrimaryLocation W137262571 @default.
- W13726257 hasRelatedWork W13726257 @default.
- W13726257 hasRelatedWork W2005028381 @default.
- W13726257 hasRelatedWork W2009072861 @default.
- W13726257 hasRelatedWork W2067805954 @default.
- W13726257 hasRelatedWork W2083129805 @default.
- W13726257 hasRelatedWork W2092213743 @default.
- W13726257 hasRelatedWork W2104473717 @default.
- W13726257 hasRelatedWork W2107832950 @default.
- W13726257 hasRelatedWork W2797587270 @default.
- W13726257 hasRelatedWork W2187901179 @default.
- W13726257 hasVolume "26" @default.
- W13726257 isParatext "false" @default.
- W13726257 isRetracted "false" @default.
- W13726257 magId "13726257" @default.
- W13726257 workType "article" @default.