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• W137278791 abstract "The erbB2 gene encodes a 185-kDa transmembrane glycoprotein that is a member of the type I family of receptor tyrosine kinases (RTK) which also includes epidermal growth factor (EGF) receptor, ErbB3, and ErbB4. Amplification and/or overexpression of erbB2 is observed in human tumors arising at many sites, including the breast and the ovaries, where it correlates with an unfavorable patient prognosis. Its role in cancer development and its accessible location on the cell surface make ErbB2 a target for directed therapy. For reviews related to the biology of ErbB2 as well as to its mechanism of activation, the reader is referred to two recent publications (Hynes and Stern 1994; Dougall et al. 1994).KeywordsEpidermal Growth Factor ReceptorErbB2 ReceptorIntracellular ExpressionErbB2 ProteinHC11 CellThese keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves." @default.
• W137278791 created "2016-06-24" @default.
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• W137278791 date "1996-01-01" @default.
• W137278791 modified "2023-09-27" @default.
• W137278791 title "Intervention in Receptor Tyrosine Kinase-Mediated Pathways: Recombinant Antibody Fusion Proteins Targeted to ErbB2" @default.
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• W137278791 doi "https://doi.org/10.1007/978-3-642-80071-9_8" @default.
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