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- W137288095 abstract "1652 Objectives: The purpose of this study is to compare the pre-operative Fluorine 18-fluoro-2-deoxy-glucose positron emission tomography (18F FDG-PET) scan and intra-operative gamma probe in the detection of tumor recurrence in patients with colorectal cancer. Methods: Twenty-one patients (12 females, 9 males) with a mean age of 54 (range 31 – 78 years) were enrolled in this study. All patients were diagnosed with recurrent colorectal cancer by rising CEA with positive FDG PET scan. The time interval between the surgery and PET scan was less than one month. For intra-operative gamma probe studies the patients were injected 10-15 mCi F-18 FDG approximately 30 minutes before the surgery. The gamma probe used in this study was a Neoprobe 1000 model. Results: Pre-operative PET scan and intra-operative gamma probe detected 48 and 45 lesions, respectively. Total 58 tissues were found suspicious and 50 of them were sent to pathology. Thirty-seven of the 50 tissues sent to pathology were tumor positive and 13 were tumor negative. When correlated with final pathology results, 31 of the lesions seen on PET scan were true positive (TP) and 9 were false positive (FP) and 35 of the lesions detected by gamma probe were TP and 8 were FP. Both PET and intra-operative gamma probe were TP in 29 lesions. The sensitivity and positive predictive value (PPV) of pre-operative PET scan and intra-operative gamma probe were 83.7%-77.5% and 94.5%-81.4%, respectively. Conclusions: In the detection of colorectal cancer recurrence, intra-operative gamma probe has higher sensitivity and PPV than PET scan. However, pre-operative PET images serve surgeons as a tumor map and help them easily find tumors using gamma probe in the operation room." @default.
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- W137288095 date "2007-05-01" @default.
- W137288095 modified "2023-09-27" @default.
- W137288095 title "Comparison of pre-operative FDG-PET scan and intra-operative gamma probe in the detection of colorectal cancer recurrence" @default.
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