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• W137329672 abstract "Ageing limbs show spontaneous reduction in both bone mass and skeletal muscle mass, accompanied by reduced functional capacity of these tissues, an increase in bone and joint disorders and muscle weakness. With reduced muscle activity or limb immobilization, there is also a progressive involution of muscle tissue, which has been termed sarcopenia. It has been proposed that growth hormone (GH) could counteract some of these ageing changes observed in bone and muscle. The authors have developed an aged rat model with limb immobilization, using 24-month-old male Wistar rats whose right hindlimbs were immobilized by external fixation or plaster of Paris for 4 weeks. In some of the immobilized rats, GH was also administered subcutaneously five times weekly for 3 1/2 weeks. At sacrifice, skeletal muscles of the hindlimbs were taken for biochemical, histological and ultrastructural studies. The results showed that 4 weeks of immobilization caused a large reduction in muscle mass (about 40%). Administration of GH was able to slow down this weight loss quite significantly. Biochemical studies showed that the activity of creatine phosphokinase in the immobilized gastrocnemius muscle was reduced (-18%), while acid phosphatase was greatly elevated (+37%). In addition, parameters of the effects of oxidative stress on muscle proteins and lipids were also examined. Protein oxidation as measured by protein carbonyl assay was 215% higher in immobilized gastrocnemius muscle, which was considerably reduced after GH administration. Also, measuring lipid peroxidation using the thiobarbituric acid reactive substances assay showed a marked increase of 131% in immobilized gastrocnemius muscles compared to controls. Application of GH to immobilized animals checked this increase almost completely. The above, as well as previous studies, showed that immobilization may be a causative factor in the elevation of oxidative stress in aged skeletal muscle. This oxidative damage is accompanied by other biochemical and morphological changes indicative of muscle damage and degeneration. Administration of GH to immobilized ageing animals can ameliorate some of these muscle changes and considerably reduce the oxidative damage due to immobilization." @default.
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• W137329672 date "1998-01-01" @default.
• W137329672 modified "2023-09-26" @default.
• W137329672 title "Effect of growth hormone on oxidative stress in immobilized muscles of old animals" @default.
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• W137329672 doi "https://doi.org/10.1007/978-3-0348-8958-2_13" @default.
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