FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W137339591> ?p ?o ?g. }

• W137339591 abstract "The important role played by vascular factors in the pathogenesis of neurodegenerative disease has been increasingly realised over recent years. The nature and impact of ocular and systemic vascular dysfunction in the pathogenesis of comparable neurodegenerative diseases such as glaucoma and Alzheimer’s disease (AD) has however never been fully explored. The aim of this thesis was therefore to investigate the presence of macro- and micro-vascular alterations in both glaucoma and AD and to explore the relationships between these two chronic, slowly progressive neurodegenerative diseases. The principle sections and findings of this work were: 1. Is the eye a window to the brain? Retinal vascular dysfunction in Alzheimer’s disease · Mild newly diagnosed AD patients demonstrated ocular vascular dysfunction, in the form of an altered retinal vascular response to flicker light, which correlated with their degree of cognitive impairment. 2. Ocular and systemic vascular abnormalities in newly diagnosed normal tension glaucoma (NTG) patients · NTG patients demonstrated an altered retinal arterial constriction response to flicker light along with an increased systemic arterial stiffness and carotid artery intima-media thickness (IMT). These findings were not replicated by healthy age matched controls. 3. Ocular vascular dysregulation in AD compares to both POAG and NTG · AD patients demonstrated altered retinal arterial reactivity to flicker light which was comparable to that of POAG patients and altered baseline venous reactivity which was comparable to that of NTG patients. Neither alteration was replicated by healthy controls. 4. POAG and NTG: two separate diseases or one continuous entity? The vascular perspective · POAG and NTG patients demonstrated comparable alterations in nocturnal systolic blood pressure (SBP) variability, ocular perfusion pressure, retinal vascular reactivity, systemic arterial stiffness and carotid IMT. · Nocturnal SBP variability was found to correlate with both retinal artery baseline diameter fluctuation and carotid IMT across the glaucoma groups." @default.
• W137339591 created "2016-06-24" @default.
• W137339591 creator A5071161419 @default.
• W137339591 date "2012-05-03" @default.
• W137339591 modified "2023-09-26" @default.
• W137339591 title "Ocular and systemic vascular dysfunction in neurodegenerative disease" @default.
• W137339591 cites W103320257 @default.
• W137339591 cites W105688089 @default.
• W137339591 cites W133596747 @default.
• W137339591 cites W147739434 @default.
• W137339591 cites W1486585438 @default.
• W137339591 cites W1487820738 @default.
• W137339591 cites W1495370737 @default.
• W137339591 cites W1496028880 @default.
• W137339591 cites W1499650201 @default.
• W137339591 cites W1504492140 @default.
• W137339591 cites W1511013913 @default.
• W137339591 cites W1512487996 @default.
• W137339591 cites W1515337665 @default.
• W137339591 cites W1515929023 @default.
• W137339591 cites W1516536009 @default.
• W137339591 cites W1516540568 @default.
• W137339591 cites W1520259177 @default.
• W137339591 cites W1527647899 @default.
• W137339591 cites W1530648036 @default.
• W137339591 cites W1534628288 @default.
• W137339591 cites W1545654914 @default.
• W137339591 cites W1546351357 @default.
• W137339591 cites W1550195835 @default.
• W137339591 cites W1551303317 @default.
• W137339591 cites W1552605193 @default.
• W137339591 cites W1553065348 @default.
• W137339591 cites W1555489744 @default.
• W137339591 cites W1556712597 @default.
• W137339591 cites W1570302318 @default.
• W137339591 cites W1591054099 @default.
• W137339591 cites W166208756 @default.
• W137339591 cites W1662750915 @default.
• W137339591 cites W168394801 @default.
• W137339591 cites W1699184314 @default.
• W137339591 cites W1707178069 @default.
• W137339591 cites W172046951 @default.
• W137339591 cites W1774266184 @default.
• W137339591 cites W180565751 @default.
• W137339591 cites W1847168837 @default.
• W137339591 cites W185273151 @default.
• W137339591 cites W1919291000 @default.
• W137339591 cites W1923262640 @default.
• W137339591 cites W1936592935 @default.
• W137339591 cites W194563866 @default.
• W137339591 cites W195116966 @default.
• W137339591 cites W1956605984 @default.
• W137339591 cites W1963965036 @default.
• W137339591 cites W1965756300 @default.
• W137339591 cites W1965780404 @default.
• W137339591 cites W1966451439 @default.
• W137339591 cites W1967272941 @default.
• W137339591 cites W1968855399 @default.
• W137339591 cites W1968991467 @default.
• W137339591 cites W1969818467 @default.
• W137339591 cites W1969880417 @default.
• W137339591 cites W1969967464 @default.
• W137339591 cites W1970018958 @default.
• W137339591 cites W1970187158 @default.
• W137339591 cites W1971911776 @default.
• W137339591 cites W1974028299 @default.
• W137339591 cites W1974447956 @default.
• W137339591 cites W1974448118 @default.
• W137339591 cites W1975414559 @default.
• W137339591 cites W1976274212 @default.
• W137339591 cites W1976414968 @default.
• W137339591 cites W1976592551 @default.
• W137339591 cites W1978530682 @default.
• W137339591 cites W1978541641 @default.
• W137339591 cites W1979221552 @default.
• W137339591 cites W1979361590 @default.
• W137339591 cites W1980164623 @default.
• W137339591 cites W1980901540 @default.
• W137339591 cites W1981835818 @default.
• W137339591 cites W1981988093 @default.
• W137339591 cites W1982301469 @default.
• W137339591 cites W1982878020 @default.
• W137339591 cites W1983924090 @default.
• W137339591 cites W1986063398 @default.
• W137339591 cites W1986760382 @default.
• W137339591 cites W1987348055 @default.
• W137339591 cites W1987611974 @default.
• W137339591 cites W1989629074 @default.
• W137339591 cites W1990596611 @default.
• W137339591 cites W1991332502 @default.
• W137339591 cites W1991396032 @default.
• W137339591 cites W1992390260 @default.
• W137339591 cites W1993169971 @default.
• W137339591 cites W1993775827 @default.
• W137339591 cites W1995994527 @default.
• W137339591 cites W1996603221 @default.
• W137339591 cites W1996784244 @default.
• W137339591 cites W1997042103 @default.
• W137339591 cites W1998673029 @default.
• W137339591 cites W2000060946 @default.

• next