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- W137365727 abstract "SummaryAfter birth, oxidative phosphorylation capacity of rat liver mitochondria increases within 2-3 hours. (1) One of the most important factors limiting the rate of oxidative phosphorylation, at birth is the rate of ATPase-ATPsynthase. After mitochondrial maturation, the main step controlling succinate oxidation coupled to ATP synthesis becomes the supply of reducing equivalents.(2) This maturation which is accompanied by an increase in the mitochondrial adenine nucleotide contents (Aprille and Asimakis, 1980, Arch. Biochem. Biophys. 201, 564–575) can be inhibited by glucose injection at birth. Glucose injection also prevented the adenine nucleotide increase and slightly decreased the content of liver cAMP and cGMP. Dibutyryl-cAMP prevented the glucose effect while a rise of cGMP induced by nitroprusside or 8-Br-cGMP inhibited mitochondrial maturation, as did glucose.(3) Glucose did not significantly modify the rate of [35S]methionine incorporation into mitochondrial proteins. However, the normal increase in the rate of ATP synthesis could be prevented by in vivo injection of either cycloheximide or thiamphenicol, specific inhibitors of nuclear and mitochondrial protein synthesis, respectively. (4) In conclusion, the improvement of the ATPase-ATPsynthase efficiency observed shortly after birth involves both a direct regulation of the enzyme due to the increase of the adenine nucleotide pool, this increase being under hormonal control, and a new synthesis of ATPase-ATPsynthase subunits encoded by nuclear and mitochondrial DNA." @default.
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- W137365727 date "1992-01-01" @default.
- W137365727 modified "2023-09-25" @default.
- W137365727 title "Regulation by Adenine Nucleotides, Cyclic Nucleotides and Protein Synthesis of the Maturation of Rat Liver Mitochondrial Functions" @default.
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- W137365727 doi "https://doi.org/10.1007/978-3-0348-7315-4_9" @default.
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