Matches in SemOpenAlex for { <https://semopenalex.org/work/W137367838> ?p ?o ?g. }
Showing items 1 to 67 of
67
with 100 items per page.
- W137367838 abstract "System xc− is a chloride-dependent, cystine/glutamate exchanger which is expressed in many cell types including neurons, glia, fibroblasts and macrophages. Previous studies in our lab have demonstrated that chloride increases the affinity of cystine for the transport system. However, it is not currently known whether System - x-c− -mediated cystine/glutamate exchange requires the net influx of chloride into the cell. Using a Xenopus oocyte expression system and a two-electrode voltage clamp, we sought to determine if chloride transport was thermodynamically coupled to cystine/glutamate exchange. Here we report that System xc−-mediated currents were observed upon exposure to cystine in a dose dependent manner. Furthermore, these currents exhibit a Km of 40 μM for cystine which is similar to the previous reported value obtained from radioactive uptake assays. Finally, we report that the observed current is insensitive to changes in extracellular chloride. Specifically, we observed that there was no variation in the reversal potential of the observed currents. These data demonstrate that system xc−is electrogenic and suggest that cystine/glutamate exchange may not be thermodynamically coupled to chloride transport." @default.
- W137367838 created "2016-06-24" @default.
- W137367838 creator A5021088904 @default.
- W137367838 creator A5033251957 @default.
- W137367838 creator A5053882398 @default.
- W137367838 date "2007-04-01" @default.
- W137367838 modified "2023-09-26" @default.
- W137367838 title "System xc‐ is an electrogenic cystine/glutamate exchanger" @default.
- W137367838 doi "https://doi.org/10.1096/fasebj.21.5.a244-d" @default.
- W137367838 hasPublicationYear "2007" @default.
- W137367838 type Work @default.
- W137367838 sameAs 137367838 @default.
- W137367838 citedByCount "0" @default.
- W137367838 crossrefType "journal-article" @default.
- W137367838 hasAuthorship W137367838A5021088904 @default.
- W137367838 hasAuthorship W137367838A5033251957 @default.
- W137367838 hasAuthorship W137367838A5053882398 @default.
- W137367838 hasBestOaLocation W1373678381 @default.
- W137367838 hasConcept C104317684 @default.
- W137367838 hasConcept C12554922 @default.
- W137367838 hasConcept C170493617 @default.
- W137367838 hasConcept C178790620 @default.
- W137367838 hasConcept C181199279 @default.
- W137367838 hasConcept C185592680 @default.
- W137367838 hasConcept C2777608289 @default.
- W137367838 hasConcept C2778695967 @default.
- W137367838 hasConcept C2779201268 @default.
- W137367838 hasConcept C2779535977 @default.
- W137367838 hasConcept C28406088 @default.
- W137367838 hasConcept C55493867 @default.
- W137367838 hasConcept C61174792 @default.
- W137367838 hasConcept C79879829 @default.
- W137367838 hasConcept C86803240 @default.
- W137367838 hasConceptScore W137367838C104317684 @default.
- W137367838 hasConceptScore W137367838C12554922 @default.
- W137367838 hasConceptScore W137367838C170493617 @default.
- W137367838 hasConceptScore W137367838C178790620 @default.
- W137367838 hasConceptScore W137367838C181199279 @default.
- W137367838 hasConceptScore W137367838C185592680 @default.
- W137367838 hasConceptScore W137367838C2777608289 @default.
- W137367838 hasConceptScore W137367838C2778695967 @default.
- W137367838 hasConceptScore W137367838C2779201268 @default.
- W137367838 hasConceptScore W137367838C2779535977 @default.
- W137367838 hasConceptScore W137367838C28406088 @default.
- W137367838 hasConceptScore W137367838C55493867 @default.
- W137367838 hasConceptScore W137367838C61174792 @default.
- W137367838 hasConceptScore W137367838C79879829 @default.
- W137367838 hasConceptScore W137367838C86803240 @default.
- W137367838 hasIssue "5" @default.
- W137367838 hasLocation W1373678381 @default.
- W137367838 hasOpenAccess W137367838 @default.
- W137367838 hasPrimaryLocation W1373678381 @default.
- W137367838 hasRelatedWork W1984867784 @default.
- W137367838 hasRelatedWork W1994090017 @default.
- W137367838 hasRelatedWork W2044939547 @default.
- W137367838 hasRelatedWork W2045178775 @default.
- W137367838 hasRelatedWork W2058115294 @default.
- W137367838 hasRelatedWork W2073218614 @default.
- W137367838 hasRelatedWork W2125357072 @default.
- W137367838 hasRelatedWork W2323415284 @default.
- W137367838 hasRelatedWork W2922279059 @default.
- W137367838 hasRelatedWork W4244664902 @default.
- W137367838 hasVolume "21" @default.
- W137367838 isParatext "false" @default.
- W137367838 isRetracted "false" @default.
- W137367838 magId "137367838" @default.
- W137367838 workType "article" @default.