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• W137418438 endingPage "87" @default.
• W137418438 startingPage "167" @default.
• W137418438 abstract "The series of processes that enable a cell to grow and produce two daughter cells is known as the cell division cycle. The past 20 years have witnessed an impressive advance in our understanding of the mechanisms that operate during cell cycle progression at the cellular, molecular, genetic and genomic levels. One of the challenges ahead is to understand cell proliferation control in the context of a developing or an adult organism. This involves not only learning how cells divide but also how arrested cells are recruited into the cell division pool or, alternatively, how and when they exit the cell cycle, make cell fate decisions and initiate a variety of differentiation pathways. One of the ways to exit the cell cycle as a prerequisite for differentiation is to enter the endocycle programme, whereby cells undergo successive rounds of genome duplication without going through mitosis. Consequently, the nuclear DNA content increases exponentially and cells become polyploid. Therefore, it is crucial for cell homeostasis to have a strict control on the switch from the cell cycle to the endocycle programme as well as on the number of endoreduplication rounds to be undergone. Occurrence of endocycles is far more frequent in plants than in animals (Edgar and Orr-Weaver, 2001; Larkins et al., 2001). In plants, endoreduplication is in many cases, although not exclusively, associated with an increase in cell size. Highly specialized differentiation pathways are also associated with endocycle progression, in some cases as a consequence of the need to increase metabolic activity, for example, during nodulation in legumes (Kondorosi et al., 2000, 2004), during nematode infection (Favery et al., 2002), during endosperm development (Lopes and Larkins, 1993; Larkins et al., 2001) or during fruit maturation (Joubes and Chevalier, 2000)." @default.
• W137418438 created "2016-06-24" @default.
• W137418438 creator A5015101325 @default.
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• W137418438 creator A5086949607 @default.
• W137418438 date "2008-01-01" @default.
• W137418438 modified "2023-10-17" @default.
• W137418438 title "Endoreduplication control during plant development." @default.
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