FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W137422730> ?p ?o ?g. }

• W137422730 endingPage "23" @default.
• W137422730 startingPage "22" @default.
• W137422730 abstract "Introduction. The molecular pathogenesis of Peyronie's Disease (PD) remains unclear more than 250 years after its initial description. Because of this, no test is currently available to accurately predict PD progression among those affected. Aim. To investigate the expression of wound healing and fibrosis-associated proteins in primary cell cultures of PD fibroblasts to determine whether altered protein expression patterns can be used as predictors of clinical course and natural history. Methods. Primary cell cultures derived from normal Tunica albuginea tissue and PD plaque tissue were examined by immuno-cytochemistry. Protein expression profiles were analyzed by Surface-Enhanced Laser Desorption/ Ionization Time-of-Flight Mass Spectrometry (SELDI-TOF-MS) and Western immunoblotting. Main Outcome Measures. Expression of wound healing and fibrosis-associated proteins and protein expression patterns were assessed. Results. Statistically significant increases in smooth muscle a-actin, b-catenin, and Heat shock proteins (Hsp47) were identified in cells derived from PD relative to cells derived from normal Tunica albuginea tissue. Changes in TGFb-1 receptor and Fibronectin were also observed. In addition, altered expression of additional as yet unidentified proteins at 4.7, 8.9, 10.8, 16.8, and 76.8 kDa were detected by complementary SELDI-TOF-MS approaches. Conclusions. Primary cells derived from PD plaques display up-regulated expression of several proteins that are established components of fibrosis and wound healing. In addition, changes in other, as yet unidentified proteins were measured. It will be of interest to conduct further studies to see whether these dysregulated protein peaks represent potential biological markers of disease progression. De Young LX, Bella AJ, O'Gorman DB, Gan BS, Lim KB, and BrockGB. Protein biomarker analysis of primary Peyronie's disease cells. J Sex Med 2010;7:99-106." @default.
• W137422730 created "2016-06-24" @default.
• W137422730 creator A5022432735 @default.
• W137422730 creator A5043619141 @default.
• W137422730 creator A5059713040 @default.
• W137422730 date "2011-02-01" @default.
• W137422730 modified "2023-09-25" @default.
• W137422730 title "Protein biomarker analysis of primary Peyronie's disease cells" @default.
• W137422730 cites W1530976880 @default.
• W137422730 cites W1560197728 @default.
• W137422730 cites W1572089739 @default.
• W137422730 cites W1967627103 @default.
• W137422730 cites W2009368567 @default.
• W137422730 cites W2015514078 @default.
• W137422730 cites W2019200461 @default.
• W137422730 cites W2019425946 @default.
• W137422730 cites W2021547491 @default.
• W137422730 cites W2026297359 @default.
• W137422730 cites W2034724589 @default.
• W137422730 cites W2041614750 @default.
• W137422730 cites W2043691868 @default.
• W137422730 cites W2046420403 @default.
• W137422730 cites W2047475499 @default.
• W137422730 cites W2061780160 @default.
• W137422730 cites W2065096738 @default.
• W137422730 cites W2066488908 @default.
• W137422730 cites W2069491458 @default.
• W137422730 cites W2071457376 @default.
• W137422730 cites W2080783616 @default.
• W137422730 cites W2082229981 @default.
• W137422730 cites W2090415578 @default.
• W137422730 cites W2096951611 @default.
• W137422730 cites W2101752626 @default.
• W137422730 cites W2116902092 @default.
• W137422730 cites W2117443766 @default.
• W137422730 cites W2119180373 @default.
• W137422730 cites W2128537563 @default.
• W137422730 cites W2141486934 @default.
• W137422730 cites W2157690383 @default.
• W137422730 cites W2228293976 @default.
• W137422730 cites W2324331282 @default.
• W137422730 cites W2027064430 @default.
• W137422730 cites W2089125259 @default.
• W137422730 hasPublicationYear "2011" @default.
• W137422730 type Work @default.
• W137422730 sameAs 137422730 @default.
• W137422730 citedByCount "0" @default.
• W137422730 crossrefType "journal-article" @default.
• W137422730 hasAuthorship W137422730A5022432735 @default.
• W137422730 hasAuthorship W137422730A5043619141 @default.
• W137422730 hasAuthorship W137422730A5059713040 @default.
• W137422730 hasConcept C104317684 @default.
• W137422730 hasConcept C105702510 @default.
• W137422730 hasConcept C142724271 @default.
• W137422730 hasConcept C189165786 @default.
• W137422730 hasConcept C203014093 @default.
• W137422730 hasConcept C204232928 @default.
• W137422730 hasConcept C205260736 @default.
• W137422730 hasConcept C2777786686 @default.
• W137422730 hasConcept C2779134260 @default.
• W137422730 hasConcept C2779145901 @default.
• W137422730 hasConcept C2780269544 @default.
• W137422730 hasConcept C2780350170 @default.
• W137422730 hasConcept C2780559512 @default.
• W137422730 hasConcept C2780942790 @default.
• W137422730 hasConcept C2781197716 @default.
• W137422730 hasConcept C46111723 @default.
• W137422730 hasConcept C502942594 @default.
• W137422730 hasConcept C55493867 @default.
• W137422730 hasConcept C71924100 @default.
• W137422730 hasConcept C86492073 @default.
• W137422730 hasConcept C86803240 @default.
• W137422730 hasConcept C95444343 @default.
• W137422730 hasConceptScore W137422730C104317684 @default.
• W137422730 hasConceptScore W137422730C105702510 @default.
• W137422730 hasConceptScore W137422730C142724271 @default.
• W137422730 hasConceptScore W137422730C189165786 @default.
• W137422730 hasConceptScore W137422730C203014093 @default.
• W137422730 hasConceptScore W137422730C204232928 @default.
• W137422730 hasConceptScore W137422730C205260736 @default.
• W137422730 hasConceptScore W137422730C2777786686 @default.
• W137422730 hasConceptScore W137422730C2779134260 @default.
• W137422730 hasConceptScore W137422730C2779145901 @default.
• W137422730 hasConceptScore W137422730C2780269544 @default.
• W137422730 hasConceptScore W137422730C2780350170 @default.
• W137422730 hasConceptScore W137422730C2780559512 @default.
• W137422730 hasConceptScore W137422730C2780942790 @default.
• W137422730 hasConceptScore W137422730C2781197716 @default.
• W137422730 hasConceptScore W137422730C46111723 @default.
• W137422730 hasConceptScore W137422730C502942594 @default.
• W137422730 hasConceptScore W137422730C55493867 @default.
• W137422730 hasConceptScore W137422730C71924100 @default.
• W137422730 hasConceptScore W137422730C86492073 @default.
• W137422730 hasConceptScore W137422730C86803240 @default.
• W137422730 hasConceptScore W137422730C95444343 @default.
• W137422730 hasLocation W1374227301 @default.
• W137422730 hasOpenAccess W137422730 @default.
• W137422730 hasPrimaryLocation W1374227301 @default.

• next