FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W137463065> ?p ?o ?g. }

• W137463065 endingPage "97" @default.
• W137463065 startingPage "384" @default.
• W137463065 abstract "Although transgenic hepatocarcinogenesis has been accomplished in the mouse with a number of genetic constructs targeting the oncogene to expression primarily in the liver, no example of this process has yet been developed in the rat. Because our understanding of the multistage nature of hepatocarcinogenesis is most advanced in the rat, we have developed a strain of transgenic rats carrying the promoter-enhancer sequences of the mouse albumin gene linked 5' to the simian virus-40 T antigen gene. A line of transgenic rats bearing this transgene has been developed from a single founder female. Five to six copies of the transgene, possibly in tandem, occur within the genome of the transgenic animals, which are maintained by heterozygous matings. Livers of transgenic animals are histologically normal after weaning; at 2 months of age, small foci of vacuolated cells appear in this organ. By 4 months of age, all animals exhibit focal lesions and nodules consisting primarily of small basophilic cells, many of which exhibit considerable cytoplasmic vacuolization. Mating of animals each bearing the transgene results in rats with a demyelinating condition that develops acutely in pregnant females and more chronically in males. Ultrastructural studies of these cells indicate that the vacuoles contain substantial amounts of glycogen, with the cells resembling hepatoblasts. Malignant neoplasms with both a glandular and a hepatoblastoma/hepatocellular carcinoma pattern arise from the nodules. Enzyme and immunohistochemical studies of all lesions reveal many similarities in gene expression to comparable lesions in rats subjected to chemically induced hepatocarcinogenesis, with certain exceptions. The placental form of glutathione-S-transferase is absent from all lesions in the transgenic animal, as is the expression of connexin 32. A significant number of lesions express serum albumin, and many, but not all, exhibit the T antigen. Lesions expressing the T antigen also contain stainable amounts of the p53 gene product; by contrast, normal hepatocytes express only very low levels of the T antigen within their nuclei and no demonstrable p53. All of the animals develop hepatic lesions, and approximately one-third also develop adenomas and carcinomas derived from the islet cells of the pancreas. Although there are differences in the morphology, biology, and genetic expression in early and late hepatic lesions in this strain of transgenic rat, many similarities also occur, making this a potential model system with which to study the interactions of environmental factors with a genetic program for hepatocarcinogenesis." @default.
• W137463065 created "2016-06-24" @default.
• W137463065 creator A5017792432 @default.
• W137463065 creator A5032962215 @default.
• W137463065 creator A5037068294 @default.
• W137463065 creator A5043317605 @default.
• W137463065 creator A5047219291 @default.
• W137463065 creator A5047762081 @default.
• W137463065 creator A5054458975 @default.
• W137463065 creator A5072181966 @default.
• W137463065 creator A5076724444 @default.
• W137463065 creator A5080742943 @default.
• W137463065 date "1994-08-01" @default.
• W137463065 modified "2023-10-16" @default.
• W137463065 title "Transgenic hepatocarcinogenesis in the rat." @default.
• W137463065 cites W1862988248 @default.
• W137463065 cites W1924015987 @default.
• W137463065 cites W1982882974 @default.
• W137463065 cites W2002085824 @default.
• W137463065 cites W2002359452 @default.
• W137463065 cites W2014897341 @default.
• W137463065 cites W2035883498 @default.
• W137463065 cites W2038745712 @default.
• W137463065 cites W2039713619 @default.
• W137463065 cites W2053275898 @default.
• W137463065 cites W2063450941 @default.
• W137463065 cites W2065090175 @default.
• W137463065 cites W2072319696 @default.
• W137463065 cites W2086187259 @default.
• W137463065 cites W2095971990 @default.
• W137463065 cites W2096428903 @default.
• W137463065 cites W2102956442 @default.
• W137463065 cites W2103780976 @default.
• W137463065 cites W2104428993 @default.
• W137463065 cites W2106359638 @default.
• W137463065 cites W2131558473 @default.
• W137463065 cites W2131701955 @default.
• W137463065 cites W2132284280 @default.
• W137463065 cites W2163269987 @default.
• W137463065 cites W21751534 @default.
• W137463065 cites W2202834200 @default.
• W137463065 cites W2415377930 @default.
• W137463065 cites W2418323835 @default.
• W137463065 cites W2467860489 @default.
• W137463065 cites W314826190 @default.
• W137463065 cites W71910563 @default.
• W137463065 cites W86447988 @default.
• W137463065 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/1887380" @default.
• W137463065 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/8053496" @default.
• W137463065 hasPublicationYear "1994" @default.
• W137463065 type Work @default.
• W137463065 sameAs 137463065 @default.
• W137463065 citedByCount "19" @default.
• W137463065 countsByYear W1374630652017 @default.
• W137463065 countsByYear W1374630652023 @default.
• W137463065 crossrefType "journal-article" @default.
• W137463065 hasAuthorship W137463065A5017792432 @default.
• W137463065 hasAuthorship W137463065A5032962215 @default.
• W137463065 hasAuthorship W137463065A5037068294 @default.
• W137463065 hasAuthorship W137463065A5043317605 @default.
• W137463065 hasAuthorship W137463065A5047219291 @default.
• W137463065 hasAuthorship W137463065A5047762081 @default.
• W137463065 hasAuthorship W137463065A5054458975 @default.
• W137463065 hasAuthorship W137463065A5072181966 @default.
• W137463065 hasAuthorship W137463065A5076724444 @default.
• W137463065 hasAuthorship W137463065A5080742943 @default.
• W137463065 hasConcept C102230213 @default.
• W137463065 hasConcept C104317684 @default.
• W137463065 hasConcept C141035611 @default.
• W137463065 hasConcept C142724271 @default.
• W137463065 hasConcept C153911025 @default.
• W137463065 hasConcept C203014093 @default.
• W137463065 hasConcept C204232928 @default.
• W137463065 hasConcept C2778019345 @default.
• W137463065 hasConcept C502942594 @default.
• W137463065 hasConcept C54355233 @default.
• W137463065 hasConcept C71924100 @default.
• W137463065 hasConcept C86803240 @default.
• W137463065 hasConceptScore W137463065C102230213 @default.
• W137463065 hasConceptScore W137463065C104317684 @default.
• W137463065 hasConceptScore W137463065C141035611 @default.
• W137463065 hasConceptScore W137463065C142724271 @default.
• W137463065 hasConceptScore W137463065C153911025 @default.
• W137463065 hasConceptScore W137463065C203014093 @default.
• W137463065 hasConceptScore W137463065C204232928 @default.
• W137463065 hasConceptScore W137463065C2778019345 @default.
• W137463065 hasConceptScore W137463065C502942594 @default.
• W137463065 hasConceptScore W137463065C54355233 @default.
• W137463065 hasConceptScore W137463065C71924100 @default.
• W137463065 hasConceptScore W137463065C86803240 @default.
• W137463065 hasIssue "2" @default.
• W137463065 hasLocation W1374630651 @default.
• W137463065 hasOpenAccess W137463065 @default.
• W137463065 hasPrimaryLocation W1374630651 @default.
• W137463065 hasRelatedWork W1585276076 @default.
• W137463065 hasRelatedWork W1984495721 @default.
• W137463065 hasRelatedWork W2008381783 @default.
• W137463065 hasRelatedWork W2011159314 @default.

• next