Matches in SemOpenAlex for { <https://semopenalex.org/work/W137463437> ?p ?o ?g. }
Showing items 1 to 70 of
70
with 100 items per page.
- W137463437 endingPage "99.41" @default.
- W137463437 startingPage "99.41" @default.
- W137463437 abstract "Abstract Purpose: We studied the role of two different regulatory T cells (CD4+CD25+Foxp3+ Treg and TGFβ/IL10-secreting CD8+ Ts) in apoptosis pathways using a mouse model of systemic lupus erythematosus (SLE). Methods: Ten-week old female NZB/NZW F1 mice were tolerized with a synthetic peptide based on anti-dsDNA VH sequences (pCons) that delays SLE symptoms or isotonic saline and killed one week later (n=6/group). After Treg and Ts isolation from spleens, gene transcript levels from three different pathways - apoptosis, T cell tolerance, and TGFβ - were examined by real-time PCR-based gene arrays (SA Biosciences). These platforms contain primers for 84 pathway-specific genes. Results: Differences in Treg mRNA between the two groups were not apparent. In Ts, however, Bcl2, survivin, COX-2, Pak7, and IL-10 transcripts were significantly elevated more than two-fold in the pCons group. The proapoptotic gene Apaf1 was also significantly downregulated, implicating inhibition of specific caspases. Western blot confirmed altered protein regulation of these genes. Bcl-2, survivin and COX-2 are direct targets of the antiapoptotic transcription factor NF-κB, and Apaf-driven signaling pathways are involved in NF-κB regulation. Conclusions: Results from these experiments provide additional insights into Ts apoptosis in SLE and could lead to novel therapeutic options designed to alter Ts biology." @default.
- W137463437 created "2016-06-24" @default.
- W137463437 creator A5032370550 @default.
- W137463437 creator A5035764571 @default.
- W137463437 creator A5048352006 @default.
- W137463437 creator A5072870816 @default.
- W137463437 creator A5073202186 @default.
- W137463437 date "2009-04-01" @default.
- W137463437 modified "2023-10-18" @default.
- W137463437 title "Anti-apoptotic Genes are Upregulated in Tolerized CD8+ Regulatory T Cells Isolated from SLE-Prone Mice (99.41)" @default.
- W137463437 doi "https://doi.org/10.4049/jimmunol.182.supp.99.41" @default.
- W137463437 hasPublicationYear "2009" @default.
- W137463437 type Work @default.
- W137463437 sameAs 137463437 @default.
- W137463437 citedByCount "0" @default.
- W137463437 crossrefType "journal-article" @default.
- W137463437 hasAuthorship W137463437A5032370550 @default.
- W137463437 hasAuthorship W137463437A5035764571 @default.
- W137463437 hasAuthorship W137463437A5048352006 @default.
- W137463437 hasAuthorship W137463437A5072870816 @default.
- W137463437 hasAuthorship W137463437A5073202186 @default.
- W137463437 hasConcept C104317684 @default.
- W137463437 hasConcept C127561419 @default.
- W137463437 hasConcept C153911025 @default.
- W137463437 hasConcept C167672396 @default.
- W137463437 hasConcept C190283241 @default.
- W137463437 hasConcept C203014093 @default.
- W137463437 hasConcept C2775975398 @default.
- W137463437 hasConcept C2776090121 @default.
- W137463437 hasConcept C2779727006 @default.
- W137463437 hasConcept C502942594 @default.
- W137463437 hasConcept C54355233 @default.
- W137463437 hasConcept C79484868 @default.
- W137463437 hasConcept C86803240 @default.
- W137463437 hasConcept C8891405 @default.
- W137463437 hasConceptScore W137463437C104317684 @default.
- W137463437 hasConceptScore W137463437C127561419 @default.
- W137463437 hasConceptScore W137463437C153911025 @default.
- W137463437 hasConceptScore W137463437C167672396 @default.
- W137463437 hasConceptScore W137463437C190283241 @default.
- W137463437 hasConceptScore W137463437C203014093 @default.
- W137463437 hasConceptScore W137463437C2775975398 @default.
- W137463437 hasConceptScore W137463437C2776090121 @default.
- W137463437 hasConceptScore W137463437C2779727006 @default.
- W137463437 hasConceptScore W137463437C502942594 @default.
- W137463437 hasConceptScore W137463437C54355233 @default.
- W137463437 hasConceptScore W137463437C79484868 @default.
- W137463437 hasConceptScore W137463437C86803240 @default.
- W137463437 hasConceptScore W137463437C8891405 @default.
- W137463437 hasIssue "1_Supplement" @default.
- W137463437 hasLocation W1374634371 @default.
- W137463437 hasOpenAccess W137463437 @default.
- W137463437 hasPrimaryLocation W1374634371 @default.
- W137463437 hasRelatedWork W130785812 @default.
- W137463437 hasRelatedWork W1992037894 @default.
- W137463437 hasRelatedWork W2026635725 @default.
- W137463437 hasRelatedWork W2031056725 @default.
- W137463437 hasRelatedWork W2059748759 @default.
- W137463437 hasRelatedWork W2075628498 @default.
- W137463437 hasRelatedWork W2103296897 @default.
- W137463437 hasRelatedWork W2200639874 @default.
- W137463437 hasRelatedWork W2890210959 @default.
- W137463437 hasRelatedWork W128433041 @default.
- W137463437 hasVolume "182" @default.
- W137463437 isParatext "false" @default.
- W137463437 isRetracted "false" @default.
- W137463437 magId "137463437" @default.
- W137463437 workType "article" @default.