Matches in SemOpenAlex for { <https://semopenalex.org/work/W137518967> ?p ?o ?g. }
Showing items 1 to 74 of
74
with 100 items per page.
- W137518967 endingPage "497" @default.
- W137518967 startingPage "491" @default.
- W137518967 abstract "The activities of cytochrome P450c17 determine which classes of steroid hormones a steroidogenic cell can produce. P450c17 is a microsomal enzyme that catalyzes both the 17α-hydroxylase and 17,20-lyase activities and is encoded by a gene termed CYP17. In the complete absence of P450c17, only progesterone, mineralocorticoids, and weak glucocorticoids can be synthesized. Hence, classical (or complete, combined) 17α-hydroxylase/17,20-lyase deficiency manifests as sexual infantilism in patients of both genetic sexes with low renin hypertension. Increasingly, partial or selective forms of P450c17 deficiency, such as isolated 17,20-lyase deficiency, are being recognized and characterized genetically and biochemically. These rare patients have provided powerful insight into the biochemical mechanisms that regulate the activities of this versatile enzyme system and how human physiology adapts to alterations in steroid balance." @default.
- W137518967 created "2016-06-24" @default.
- W137518967 creator A5055037280 @default.
- W137518967 creator A5064575852 @default.
- W137518967 date "2004-01-01" @default.
- W137518967 modified "2023-10-16" @default.
- W137518967 title "17α-Hydroxylase/17,20-Lyase Deficiency" @default.
- W137518967 cites W1570978364 @default.
- W137518967 cites W1891933871 @default.
- W137518967 cites W1963545612 @default.
- W137518967 cites W1995802297 @default.
- W137518967 cites W2019527863 @default.
- W137518967 cites W2053012453 @default.
- W137518967 cites W2059850722 @default.
- W137518967 cites W2064361691 @default.
- W137518967 cites W2095040842 @default.
- W137518967 cites W2103133230 @default.
- W137518967 cites W2126123126 @default.
- W137518967 cites W2126733133 @default.
- W137518967 cites W2129876849 @default.
- W137518967 cites W4296153575 @default.
- W137518967 doi "https://doi.org/10.1016/b0-12-475570-4/00631-4" @default.
- W137518967 hasPublicationYear "2004" @default.
- W137518967 type Work @default.
- W137518967 sameAs 137518967 @default.
- W137518967 citedByCount "0" @default.
- W137518967 crossrefType "book-chapter" @default.
- W137518967 hasAuthorship W137518967A5055037280 @default.
- W137518967 hasAuthorship W137518967A5064575852 @default.
- W137518967 hasConcept C104317684 @default.
- W137518967 hasConcept C126322002 @default.
- W137518967 hasConcept C134018914 @default.
- W137518967 hasConcept C142716871 @default.
- W137518967 hasConcept C181199279 @default.
- W137518967 hasConcept C185592680 @default.
- W137518967 hasConcept C2777269803 @default.
- W137518967 hasConcept C2780902042 @default.
- W137518967 hasConcept C526171541 @default.
- W137518967 hasConcept C55493867 @default.
- W137518967 hasConcept C71315377 @default.
- W137518967 hasConcept C71924100 @default.
- W137518967 hasConcept C86803240 @default.
- W137518967 hasConceptScore W137518967C104317684 @default.
- W137518967 hasConceptScore W137518967C126322002 @default.
- W137518967 hasConceptScore W137518967C134018914 @default.
- W137518967 hasConceptScore W137518967C142716871 @default.
- W137518967 hasConceptScore W137518967C181199279 @default.
- W137518967 hasConceptScore W137518967C185592680 @default.
- W137518967 hasConceptScore W137518967C2777269803 @default.
- W137518967 hasConceptScore W137518967C2780902042 @default.
- W137518967 hasConceptScore W137518967C526171541 @default.
- W137518967 hasConceptScore W137518967C55493867 @default.
- W137518967 hasConceptScore W137518967C71315377 @default.
- W137518967 hasConceptScore W137518967C71924100 @default.
- W137518967 hasConceptScore W137518967C86803240 @default.
- W137518967 hasLocation W1375189671 @default.
- W137518967 hasOpenAccess W137518967 @default.
- W137518967 hasPrimaryLocation W1375189671 @default.
- W137518967 hasRelatedWork W1997759048 @default.
- W137518967 hasRelatedWork W199784463 @default.
- W137518967 hasRelatedWork W2027210979 @default.
- W137518967 hasRelatedWork W2028506307 @default.
- W137518967 hasRelatedWork W2069420617 @default.
- W137518967 hasRelatedWork W2105129031 @default.
- W137518967 hasRelatedWork W2156339092 @default.
- W137518967 hasRelatedWork W2164661085 @default.
- W137518967 hasRelatedWork W2365048306 @default.
- W137518967 hasRelatedWork W2418149350 @default.
- W137518967 isParatext "false" @default.
- W137518967 isRetracted "false" @default.
- W137518967 magId "137518967" @default.
- W137518967 workType "book-chapter" @default.