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- W137660147 abstract "The plasma fibrinolytic system is responsible for the dissolution of blood clots. It thus promotes continued circulation of the blood through an unobstructed vascular bed. Unfortunately, in spite of more than 30 years of research, the identity and origin of the plasminogen activator (PA) in blood responsible for initiating and controlling this process remains uncertain (1). Much of this confusion results from the presence of multiple, functionally distinct types of PA in blood (1, 2), their inherent instability (3), and the presence of molecules in blood that inhibit them (4). In an attempt to circumvent these problems, we have begun to characterize the PAs produced by cultured endothelial cells (ECs) since available information suggests that the physiologically important vascular PA may originate from the endothelium itself (5). The purpose of this review is to summarize (1) observations that implicate the endothelium in vascular fibrinolysis; (2) experiments that delineate the fibrinolytic components produced by cultured ECs; and (3) studies indicating that the production and activity of these PAs may be influenced by exogenous agents, including some molecules associated with the thrombus itself." @default.
- W137660147 created "2016-06-24" @default.
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- W137660147 date "1984-01-01" @default.
- W137660147 modified "2023-10-18" @default.
- W137660147 title "Properties of plasminogen activators produced by endothelial cells" @default.
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- W137660147 doi "https://doi.org/10.1007/978-1-4613-2825-4_20" @default.
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