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- W137685795 abstract "The liver plays a central role in the uptake, storage, and mobilization of retinol (vitamin A) in the body. The metabolism of retinoids in the liver, where over 95% of the retinoids in the body is found, is both complex and highly regulated. Specific functions in retinoid metabolism have been described for parenchymal and fat-storing cells. Possibly, Kupffer cells may have a function in retinoid metabolism as well. Liver cell isolation procedures have been widely applied to study cell-specific functions in liver retinoid metabolism. This chapter describes methods available for the isolation, purification, and characterization of parenchymal, fat-storing, Kupffer, and endothelial cells. Isolated liver cells have been widely used to study the cellular distribution of retinoids, retinoid-binding proteins, and enzyme activities important in retinoid metabolism. The results obtained are generally consistent with in vivo data. Cell isolation procedures are currently being used to define further the respective roles of the different liver cells types in retinoid metabolism." @default.
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- W137685795 date "1990-01-01" @default.
- W137685795 modified "2023-09-25" @default.
- W137685795 title "Isolation, purification, and characterization of liver cell types" @default.
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- W137685795 doi "https://doi.org/10.1016/0076-6879(90)90008-o" @default.
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