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- W137687993 abstract "Vinyl chloride is an important human carcinogen which is metabolized to the very labile intermediate chloroethylene oxide (CEO) and to chloroacetaldehyde (CAA) which is stable. CAA reacts with cytidine and adenosine to give the fluorescent etheno products, 3,N/sup 4/-etheno C and 1,N/sup 6/-etheno A. These compounds have not been detected unequivocally in double-stranded DNA in vivo, presumably due to the unavailability of the endo nitrogens necessary for cyclization. To simulate this situation, they have used 3-methyl cytidine as a model. This reacts with CAA at physiological conditions to form small amounts of several labile products. One of these, 30% of reaction, can be stabilized by reduction with sodium cyanoborohydride to a Schiff's type base. An analogous result was obtained by Sattsangi et al. with adenosine and acetaldehyde to yield N/sup 6/-ethyl A. However, when 3-methyl cytidine was treated with acetaldehyde, a semistable addition product was obtained with and without SCBH treatment. The mechanism of this reaction and characterization of these N/sup 4/-substituted and other nucleoside-aldehyde products will be reported." @default.
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- W137687993 date "1987-05-01" @default.
- W137687993 modified "2023-09-27" @default.
- W137687993 title "Stable reaction products of 3-methyl cytidine with chloroacetaldehyde and acetaldehyde" @default.
- W137687993 hasPublicationYear "1987" @default.
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