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- W137694124 abstract "Phosphodiesterases (PDE) are a family of enzymes responsible for the metabolism of the intracellular second messengers cyclic AMP and cyclic GMP. PDE4 is a cyclic AMP specific PDE that is the major if not sole cyclic AMP metabolizing enzymes found in inflammatory and immune cells, and contributes significantly to cyclic AMP metabolism in smooth muscles. Based on its cellular and tissue distribution and the demonstration that selective inhibitors of this isozyme reduce bronchoconstriction in animals and suppress the activation of inflammatory cells, PDE4 has become an important molecular target for the development of novel therapies for asthma and COPD. This chapter will review the evidence demonstrating the ability of PDE4 inhibitors to modify airway obstruction, airway inflammation and airway remodelling and hyperreactivity, will present some preliminary findings obtained with theses compounds in clinical trials and and will discuss experimental approaches designed to identify novel compounds that maintain the beneficial activity of the initial selective PDE4 inhibitors but with a reduced tendency of elicit the gastrointestinal side effects observed with this class of compounds." @default.
- W137694124 created "2016-06-24" @default.
- W137694124 creator A5051901418 @default.
- W137694124 date "1999-01-01" @default.
- W137694124 modified "2023-09-24" @default.
- W137694124 title "Phosphodiesterase 4 (PDE4) inhibitors in asthma and chronic obstructive pulmonary disease (COPD)" @default.
- W137694124 cites W1498706619 @default.
- W137694124 cites W1502898912 @default.
- W137694124 cites W1510098440 @default.
- W137694124 cites W1510434099 @default.
- W137694124 cites W1515715671 @default.
- W137694124 cites W1516500578 @default.
- W137694124 cites W1555627355 @default.
- W137694124 cites W1572740641 @default.
- W137694124 cites W1588742331 @default.
- W137694124 cites W1604404976 @default.
- W137694124 cites W1940348917 @default.
- W137694124 cites W1964429944 @default.
- W137694124 cites W1964809170 @default.
- W137694124 cites W1966333025 @default.
- W137694124 cites W1966650769 @default.
- W137694124 cites W1967927534 @default.
- W137694124 cites W1969042898 @default.
- W137694124 cites W1970097110 @default.
- W137694124 cites W1970774232 @default.
- W137694124 cites W1970874069 @default.
- W137694124 cites W1971017097 @default.
- W137694124 cites W1971125637 @default.
- W137694124 cites W1972148544 @default.
- W137694124 cites W1973691348 @default.
- W137694124 cites W1974253631 @default.
- W137694124 cites W1974536864 @default.
- W137694124 cites W1974880581 @default.
- W137694124 cites W1974982747 @default.
- W137694124 cites W1975972186 @default.
- W137694124 cites W1977417395 @default.
- W137694124 cites W1978357433 @default.
- W137694124 cites W1978487251 @default.
- W137694124 cites W1978745043 @default.
- W137694124 cites W1979027770 @default.
- W137694124 cites W1980432303 @default.
- W137694124 cites W1980637240 @default.
- W137694124 cites W1983627939 @default.
- W137694124 cites W1983754425 @default.
- W137694124 cites W1983963555 @default.
- W137694124 cites W1984534195 @default.
- W137694124 cites W1986047818 @default.
- W137694124 cites W1988620870 @default.
- W137694124 cites W1988639771 @default.
- W137694124 cites W1988685962 @default.
- W137694124 cites W1988901842 @default.
- W137694124 cites W1989913574 @default.
- W137694124 cites W1990281506 @default.
- W137694124 cites W1991020657 @default.
- W137694124 cites W1991177887 @default.
- W137694124 cites W1991339741 @default.
- W137694124 cites W1993182513 @default.
- W137694124 cites W1993584703 @default.
- W137694124 cites W1993861182 @default.
- W137694124 cites W1994226794 @default.
- W137694124 cites W1994934244 @default.
- W137694124 cites W1996040058 @default.
- W137694124 cites W1996614035 @default.
- W137694124 cites W1997239704 @default.
- W137694124 cites W1997482219 @default.
- W137694124 cites W1997541655 @default.
- W137694124 cites W1997718249 @default.
- W137694124 cites W1998425936 @default.
- W137694124 cites W1998484752 @default.
- W137694124 cites W1999493130 @default.
- W137694124 cites W1999717807 @default.
- W137694124 cites W1999964462 @default.
- W137694124 cites W2000312049 @default.
- W137694124 cites W2003060940 @default.
- W137694124 cites W2003180244 @default.
- W137694124 cites W2003441148 @default.
- W137694124 cites W2003922574 @default.
- W137694124 cites W2006512568 @default.
- W137694124 cites W2007326882 @default.
- W137694124 cites W2007599029 @default.
- W137694124 cites W2008771436 @default.
- W137694124 cites W2009114097 @default.
- W137694124 cites W2009717512 @default.
- W137694124 cites W2010232855 @default.
- W137694124 cites W2011267749 @default.
- W137694124 cites W2011522427 @default.
- W137694124 cites W2014212748 @default.
- W137694124 cites W2015366425 @default.
- W137694124 cites W2015427570 @default.
- W137694124 cites W2015535756 @default.
- W137694124 cites W2016018338 @default.
- W137694124 cites W2016463796 @default.
- W137694124 cites W2017696617 @default.
- W137694124 cites W2018168922 @default.
- W137694124 cites W2020117331 @default.
- W137694124 cites W2020206362 @default.
- W137694124 cites W2021017717 @default.
- W137694124 cites W2021597042 @default.