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- W137701155 abstract "Mesenchymal stem cells (MSCs) migrate via the bloodstream to sites of injury, possibly attracted by inflammatory cytokines. Although many cytokines can induce stem cell migration, the underlying mechanism is not fully understood. We found that tail vein-injected MSCs migrate to the pancreas in nonobese diabetic (NOD) mice. An ELISA assay revealed that hyperglycemic NOD mice have higher pancreatic levels of interleukin-1β (IL-1β) than normal NOD mice and that IL-1β stimulates MSC migration in a Transwell assay and electric cell-substrate impedance sensing system. Microarray analysis showed that myosin light chain kinase (MLCK) is involved in IL-1β-induced MSC migration, while Western blots showed that IL-1β stimulates MLCK expression and activation and that MLCK-siRNA transfection reduces MSC migration. Kinase inhibitors, chromatin immunoprecipitation, and a knockdown study revealed that IL-1β-induced MLCK expression is regulated by the PKCδ/NF-κB signaling pathway, and a kinase inhibitor study revealed that IL-1β-induced MLCK activation occurs via the PKCα/MEK/ERK signaling pathway. These results show that IL-1β released from the pancreas of hyperglycemic NOD mice induces MSC migration and that this is dependent on MLCK expression via the PKCδ/NF-κB pathway and on MLCK activation via the PKCα/MEK/ERK signaling cascade. This study increases our understanding of the mechanisms by which MSCs home to injury sites." @default.
- W137701155 created "2016-06-24" @default.
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- W137701155 date "2015-10-01" @default.
- W137701155 modified "2023-10-02" @default.
- W137701155 title "IL-1β-Induced Mesenchymal Stem Cell Migration Involves MLCK Activation via PKC Signaling" @default.
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- W137701155 cites W1967543768 @default.
- W137701155 cites W1969644104 @default.
- W137701155 cites W1972057121 @default.
- W137701155 cites W1973121417 @default.
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- W137701155 cites W1975578801 @default.
- W137701155 cites W1977111489 @default.
- W137701155 cites W1978800133 @default.
- W137701155 cites W1981762666 @default.
- W137701155 cites W1987139499 @default.
- W137701155 cites W1994910345 @default.
- W137701155 cites W1995683052 @default.
- W137701155 cites W1996789930 @default.
- W137701155 cites W2000212892 @default.
- W137701155 cites W2001211040 @default.
- W137701155 cites W2002353472 @default.
- W137701155 cites W2003049393 @default.
- W137701155 cites W2009791343 @default.
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- W137701155 doi "https://doi.org/10.3727/096368914x685258" @default.
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