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- W137703826 abstract "Heme and non-heme iron (Fe) are taken up by enterocytes via distinct transporters but may share the same exporter protein, ferroportin (FPN). The Fe regulatory hormone, hepcidin, controls non-heme Fe absorption by inducing FPN degradation. Whether hepcidin affects heme Fe absorption is largely unknown. To address this question, we utilized stable Fe isotopes to measure heme and non-heme Fe absorption in a rodent model of Fe overload. Male Sprague Dawley rats received bi-weekly injections of PBS (control), 4 mg Fe (moderate Fe), or 12 mg Fe (high Fe) to induce Fe overload. After 2 weeks of treatment, rats were gavaged on alternate days with 57Fe as labeled ferrous sulfate and 58Fe as labeled porcine RBCs. Red cell incorporation of 57Fe and 58Fe was assessed 10-days post-dosing. Fe overload in rats increased Fe concentrations in liver (p=0.008) and spleen (p=0.002), increased levels of liver hepcidin transcripts (p=0.005), and reduced absorption of both heme (p=0.004) and nonheme Fe (p=0.01) by 69% and 63%, respectively. While humans absorb heme Fe more efficiently, non-heme Fe absorption was 2.4-times higher than heme Fe absorption in the rat (p=0.0009). Liver hepcidin had a greater association with non-heme compared to heme Fe absorption (p=0.02, ANCOVA). Hepcidin up-regulation in the rat inhibits both non-heme and heme Fe absorption but suppresses heme Fe absorption less effectively. Grant Funding Source: USDA 2008–0857 Grant Funding Source: USDA" @default.
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- W137703826 date "2013-04-01" @default.
- W137703826 modified "2023-09-23" @default.
- W137703826 title "Differential effects of hepcidin on heme and nonheme iron absorption in a rat model of iron overload" @default.
- W137703826 doi "https://doi.org/10.1096/fasebj.27.1_supplement.634.18" @default.
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