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- W13775195 abstract "Publisher Summary Sphingomyelin metabolites, particularly ceramide and sphingosine-l-phosphate, are becoming firmly established as mediators of neuronal plasticity and survival, and perturbations in sphingomyelin metabolism are increasingly recognized for its contributions to the pathogenesis of neurological disorders. Sphingolipid signaling mediates cellular responses to a remarkable array of growth factors, cytokines and neurotransmitters, but is also a prominent mediator of responses oxidative and metabolic stress. If alterations in sphingolipid do indeed play major roles in aging and age-related disease, then one goal of research on this fascinating signaling system is to identify ways to maintain the beneficial functions of sphingolipid metabolism, while preventing pathological alterations in this system. Accumulating data from analyses of postmortem tissues from patients, and experiments in animal and cell culture models, support involvement of perturbed sphingomyelin metabolism and ceramide signaling in several different neurodegenerative disorders. This chapter reviews the emerging evidence suggesting that sphingomyelin alterations play important roles in dysfunction and death of neurons in pathological conditions and that normalizing these alterations may prove effective in preventing and treating one or more of the diseases." @default.
- W13775195 created "2016-06-24" @default.
- W13775195 creator A5017444330 @default.
- W13775195 creator A5083040475 @default.
- W13775195 date "2003-01-01" @default.
- W13775195 modified "2023-10-04" @default.
- W13775195 title "Sphingomyelin and ceramide in brain aging, neuronal plasticity and neurodegenerative disorders" @default.
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