Matches in SemOpenAlex for { <https://semopenalex.org/work/W13775277> ?p ?o ?g. }
- W13775277 endingPage "25" @default.
- W13775277 startingPage "1315" @default.
- W13775277 abstract "This study analyzes the association of Epstein-Barr virus (EBV) with non-Hodgkin's lymphoma (NHL) arising in patients without pre-existing overt immunodeficiency. The authors examined 201 lymphomas (105 high-grade B-cell, 82 peripheral T-cell, 7 high-grade non-B-cell, non-T-cell, and 7 hairy-cell leukemia) for EBV gene expression by immunohistologic procedures using monoclonal antibodies to EBV latent, immediate early, and replicative infection antigens. Transformation-associated EBV latent membrane protein 1 (LMP 1) was detected in 13 (6%) NHL, comprising 4 (4%) high-grade B-cell, 8 (10%) peripheral T-cell, and 1 non-B-cell, non-T-cell lymphomas. Anaplastic large-cell lymphoma of T-cell type was consistently LMP 1-negative. EBV nuclear antigen 2 was demonstrated in only three (1%) cases. Induction of replication as defined by expression of the immediate early BamHI Z leftward reading frame 1 (BZLF1) protein was detected in five cases, but early (EA) and late (VCA and MA) lytic cycle antigens were only found in two cases and in one case, respectively. The presence of EBV was confirmed by in situ DNA hybridization in 9 of 11 EBV antigen-positive lymphomas. This study shows the surprisingly frequent presence of EBV in peripheral T-cell NHL in European patients without pre-existing overt immunodeficiency. Interestingly, most sporadic B-cell NHL are not associated with the virus. Furthermore, the usefulness of selected monoclonal antibodies for the routine immunohistological diagnosis of EBV infection was confirmed." @default.
- W13775277 created "2016-06-24" @default.
- W13775277 creator A5028628734 @default.
- W13775277 creator A5029319079 @default.
- W13775277 date "1992-06-01" @default.
- W13775277 modified "2023-10-18" @default.
- W13775277 title "A survey of Epstein-Barr virus gene expression in sporadic non-Hodgkin's lymphomas. Detection of Epstein-Barr virus in a subset of peripheral T-cell lymphomas." @default.
- W13775277 cites W15076310 @default.
- W13775277 cites W1623441181 @default.
- W13775277 cites W1696370831 @default.
- W13775277 cites W1899316739 @default.
- W13775277 cites W1908565253 @default.
- W13775277 cites W1970748912 @default.
- W13775277 cites W1972992388 @default.
- W13775277 cites W1982742147 @default.
- W13775277 cites W1984609191 @default.
- W13775277 cites W1988394632 @default.
- W13775277 cites W1991226842 @default.
- W13775277 cites W1996168666 @default.
- W13775277 cites W2001053169 @default.
- W13775277 cites W2003916661 @default.
- W13775277 cites W2005170589 @default.
- W13775277 cites W2009813063 @default.
- W13775277 cites W2012814116 @default.
- W13775277 cites W2015506669 @default.
- W13775277 cites W2016548488 @default.
- W13775277 cites W2018487476 @default.
- W13775277 cites W2024122811 @default.
- W13775277 cites W2041969360 @default.
- W13775277 cites W2042814875 @default.
- W13775277 cites W2043767263 @default.
- W13775277 cites W2061370277 @default.
- W13775277 cites W2078306979 @default.
- W13775277 cites W2080062050 @default.
- W13775277 cites W2084813631 @default.
- W13775277 cites W2086932055 @default.
- W13775277 cites W2088281436 @default.
- W13775277 cites W2091224593 @default.
- W13775277 cites W2093552644 @default.
- W13775277 cites W2095572685 @default.
- W13775277 cites W2104270344 @default.
- W13775277 cites W2107088342 @default.
- W13775277 cites W2127373373 @default.
- W13775277 cites W2129214379 @default.
- W13775277 cites W2130407917 @default.
- W13775277 cites W2134929965 @default.
- W13775277 cites W2137761819 @default.
- W13775277 cites W2152917332 @default.
- W13775277 cites W2160339795 @default.
- W13775277 cites W2160858666 @default.
- W13775277 cites W2192778188 @default.
- W13775277 cites W2279176191 @default.
- W13775277 cites W2288102405 @default.
- W13775277 cites W2313237333 @default.
- W13775277 cites W2314280421 @default.
- W13775277 cites W2318643269 @default.
- W13775277 cites W2321237021 @default.
- W13775277 cites W2327153404 @default.
- W13775277 cites W2332686457 @default.
- W13775277 cites W2402514173 @default.
- W13775277 cites W36858582 @default.
- W13775277 cites W8133033 @default.
- W13775277 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/1886555" @default.
- W13775277 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/1318639" @default.
- W13775277 hasPublicationYear "1992" @default.
- W13775277 type Work @default.
- W13775277 sameAs 13775277 @default.
- W13775277 citedByCount "37" @default.
- W13775277 countsByYear W137752772012 @default.
- W13775277 countsByYear W137752772013 @default.
- W13775277 countsByYear W137752772015 @default.
- W13775277 countsByYear W137752772017 @default.
- W13775277 countsByYear W137752772023 @default.
- W13775277 crossrefType "journal-article" @default.
- W13775277 hasAuthorship W13775277A5028628734 @default.
- W13775277 hasAuthorship W13775277A5029319079 @default.
- W13775277 hasConcept C147483822 @default.
- W13775277 hasConcept C159047783 @default.
- W13775277 hasConcept C159654299 @default.
- W13775277 hasConcept C203014093 @default.
- W13775277 hasConcept C2522874641 @default.
- W13775277 hasConcept C2776409557 @default.
- W13775277 hasConcept C2776995267 @default.
- W13775277 hasConcept C2778453870 @default.
- W13775277 hasConcept C2778847070 @default.
- W13775277 hasConcept C2779338263 @default.
- W13775277 hasConcept C2780727368 @default.
- W13775277 hasConcept C2781295983 @default.
- W13775277 hasConcept C2781375147 @default.
- W13775277 hasConcept C86803240 @default.
- W13775277 hasConceptScore W13775277C147483822 @default.
- W13775277 hasConceptScore W13775277C159047783 @default.
- W13775277 hasConceptScore W13775277C159654299 @default.
- W13775277 hasConceptScore W13775277C203014093 @default.
- W13775277 hasConceptScore W13775277C2522874641 @default.
- W13775277 hasConceptScore W13775277C2776409557 @default.
- W13775277 hasConceptScore W13775277C2776995267 @default.
- W13775277 hasConceptScore W13775277C2778453870 @default.