Matches in SemOpenAlex for { <https://semopenalex.org/work/W137755939> ?p ?o ?g. }
Showing items 1 to 81 of
81
with 100 items per page.
- W137755939 endingPage "12" @default.
- W137755939 startingPage "9" @default.
- W137755939 abstract "Since the middle of this century and especially since the 1960s and 1970s. Chinese scientists have put considerable effort and resources into the search for new antimalarial compounds extracted from Chinese traditional herbs. Archaeological findings indicate that qinghao (Artemisia annua L.) has been used as a traditional remedy in China for over two thousand years. Its antimalarial principle was finally isolated in 1971 and named artemisinin or qinghaosu (meaning the principle of qinghao in Chinese). Its rapid action, low toxicity and powerful effect against falciparum malaria made it a favored subject for research. In 1976, the unique structure of the molecule, characterized by an endoperoxide and an alternative O-C-O-C segment, was identified. The specific lactone reduction discovered during the determination of the structure opened the way for the synthesis of qinghaosu derivatives, and thereafter a series of more active and more oil- or water-soluble derivatives was developed. Subsequent studies of the structure/activity relationship led to the discovery of dihydroartemisinin, artemether and artesunate. Now qinghaosu and these three derivatives are being used around the world as effective new antimalarial drugs in the fight against falciparum malaria, including multi-drug-resistant Plasmodium falciparum. At the present time new qinghaosu analogues or derivatives are being developed and studies of their structure/activity relationships, their antimalarial mechanisms, their interaction with ferrous ions and the DNA damage associated with these processes are being actively pursued. In addition, recent studies also indicate that some qinghaosu derivatives have other bioactivities, including antiparasitic (against Schistosoma japonicum, Toxoplasma gondii and so on) and anticancer activities. Research into qinghaosu and its derivatives has already produced and will no doubt continue to produce results of the utmost importance in the fight against malaria and other diseases." @default.
- W137755939 created "2016-06-24" @default.
- W137755939 creator A5046262151 @default.
- W137755939 creator A5051504822 @default.
- W137755939 date "1998-01-01" @default.
- W137755939 modified "2023-09-22" @default.
- W137755939 title "How Chinese scientists discovered qinghaosu (artemisinin) and developed its derivatives? What are the future perspectives?" @default.
- W137755939 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/10212890" @default.
- W137755939 hasPublicationYear "1998" @default.
- W137755939 type Work @default.
- W137755939 sameAs 137755939 @default.
- W137755939 citedByCount "21" @default.
- W137755939 countsByYear W1377559392012 @default.
- W137755939 countsByYear W1377559392013 @default.
- W137755939 countsByYear W1377559392014 @default.
- W137755939 countsByYear W1377559392015 @default.
- W137755939 countsByYear W1377559392017 @default.
- W137755939 countsByYear W1377559392018 @default.
- W137755939 countsByYear W1377559392022 @default.
- W137755939 countsByYear W1377559392023 @default.
- W137755939 crossrefType "journal-article" @default.
- W137755939 hasAuthorship W137755939A5046262151 @default.
- W137755939 hasAuthorship W137755939A5051504822 @default.
- W137755939 hasConcept C142724271 @default.
- W137755939 hasConcept C185592680 @default.
- W137755939 hasConcept C203014093 @default.
- W137755939 hasConcept C2776120307 @default.
- W137755939 hasConcept C2778048844 @default.
- W137755939 hasConcept C2778059366 @default.
- W137755939 hasConcept C2778118209 @default.
- W137755939 hasConcept C2778371730 @default.
- W137755939 hasConcept C2779691961 @default.
- W137755939 hasConcept C2781160685 @default.
- W137755939 hasConcept C2781421772 @default.
- W137755939 hasConcept C556039675 @default.
- W137755939 hasConcept C71924100 @default.
- W137755939 hasConcept C86803240 @default.
- W137755939 hasConceptScore W137755939C142724271 @default.
- W137755939 hasConceptScore W137755939C185592680 @default.
- W137755939 hasConceptScore W137755939C203014093 @default.
- W137755939 hasConceptScore W137755939C2776120307 @default.
- W137755939 hasConceptScore W137755939C2778048844 @default.
- W137755939 hasConceptScore W137755939C2778059366 @default.
- W137755939 hasConceptScore W137755939C2778118209 @default.
- W137755939 hasConceptScore W137755939C2778371730 @default.
- W137755939 hasConceptScore W137755939C2779691961 @default.
- W137755939 hasConceptScore W137755939C2781160685 @default.
- W137755939 hasConceptScore W137755939C2781421772 @default.
- W137755939 hasConceptScore W137755939C556039675 @default.
- W137755939 hasConceptScore W137755939C71924100 @default.
- W137755939 hasConceptScore W137755939C86803240 @default.
- W137755939 hasLocation W1377559391 @default.
- W137755939 hasOpenAccess W137755939 @default.
- W137755939 hasPrimaryLocation W1377559391 @default.
- W137755939 hasRelatedWork W1822913646 @default.
- W137755939 hasRelatedWork W1964608625 @default.
- W137755939 hasRelatedWork W1985372630 @default.
- W137755939 hasRelatedWork W2022680659 @default.
- W137755939 hasRelatedWork W2044811771 @default.
- W137755939 hasRelatedWork W2054618296 @default.
- W137755939 hasRelatedWork W2056183462 @default.
- W137755939 hasRelatedWork W2067887960 @default.
- W137755939 hasRelatedWork W2076029682 @default.
- W137755939 hasRelatedWork W2098184601 @default.
- W137755939 hasRelatedWork W2108093239 @default.
- W137755939 hasRelatedWork W2115600413 @default.
- W137755939 hasRelatedWork W2149202606 @default.
- W137755939 hasRelatedWork W2158893859 @default.
- W137755939 hasRelatedWork W2170226796 @default.
- W137755939 hasRelatedWork W2181657564 @default.
- W137755939 hasRelatedWork W2407381016 @default.
- W137755939 hasRelatedWork W2412469344 @default.
- W137755939 hasRelatedWork W2415857352 @default.
- W137755939 hasRelatedWork W2806631171 @default.
- W137755939 hasVolume "58" @default.
- W137755939 isParatext "false" @default.
- W137755939 isRetracted "false" @default.
- W137755939 magId "137755939" @default.
- W137755939 workType "article" @default.