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- W137758432 abstract "Over the past several years our group has been examining the functional characteristics of the serotonergic biosynthetic system in the brain by subjecting it to a number of challenges including various drugs (Knapp, Mandell, 1972a, 1972b, 1973, 1975, in press; Knapp, Mandell, Geyer, 1974; Knapp, 1975; Knapp, Mandell, Bullard, 1975; Rogawski, Knapp, Mandell, 1974; Geyer, Dawsey, Mandell, 1975a; Geyer, Warbritton, Menkes, Zook, Mandell, 1975b; Geyer, Puerto, Dawsey, Knapp, Bullard, Mandell, in press, a) and environmental manipulations (Segal, Knapp, Kuczenski, Mandell, 1973; Geyer, Puerto, Menkes, Segal, Mandell, in press, b). A group of biochemical measures has evolved which appears to be useful in these explorations. As depicted in Fig. 1, they include: the high affinity uptake of tryptophan into serotonergic synaptosomes; the “amount” of soluble tryptophan hydroxylase activity in cell body and nerve ending regions (median raphe and striate cortex, respectively) after hypotonic lysis of the preparations; and the overall rate of conversion of tryptophan to serotonin (5-HT) by synaptosomes. Our experimental methods have been described in detail elsewhere (Knapp et al., 1974; Knapp, Mandell, 1975). The effects on these measures of cocaine in vitro and in vivo, alone and in combination with lithium chloride, will be described in this report." @default.
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- W137758432 date "1977-01-01" @default.
- W137758432 modified "2023-09-27" @default.
- W137758432 title "Neurobiological Antagonism of Cocaine by Lithium" @default.
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- W137758432 doi "https://doi.org/10.1007/978-1-4684-3087-5_9" @default.
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