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- W13778022 abstract "Abstract A crucial step in the development of B cells into plasma cells is the increased production of secreted immunoglobulin which occurs by differential selection of the secretory-specific polyA site. Factors involved in polyadenylation can be coupled with transcription through phosphorylation of the carboxyl-terminal domain (CTD) of RNA pol II. We analyzed loading and phosphorylation patterns of RNA Polymerase II along an identical immunoglobulin heavy chain gene expressed either in B- or plasma cells by chromatin immunoprecipitation using various antibodies. Data indicate that the switch to secreted immunoglobulin heavy chain mRNA production is influenced by increased RNA Polymerase II accumulation and CTD phosphorylation at the promoter in plasma cells. Loading of transcription factors is increased in the plasma cells. This allows for increased access of specific processing factors to the polymerase and nascent RNA. Supported by NIH-CA-86433 to C.M." @default.
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- W13778022 date "2007-04-01" @default.
- W13778022 modified "2023-09-23" @default.
- W13778022 title "Loading and phosphorylation of RNA polymerase II influence production of secretory-specific Ig heavy chain mRNA in plasma cells. (35.33)" @default.
- W13778022 doi "https://doi.org/10.4049/jimmunol.178.supp.35.33" @default.
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