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• W137802152 abstract "The anti-neutrophil cytoplasmic antibody (ANCA)-associated vasculitides (AAVs) are a group of disorders involving severe, systemic, small-vessel vasculitis and are characterized by the development of autoantibodies to the neutrophil proteins leukocyte proteinase 3 (PR3-ANCA) or myeloperoxidase (MPO-ANCA). The three AAV subgroups, namely granulomatosis with polyangiitis (GPA), microscopic polyangiitis and eosinophilic GPA (EGPA), are defined according to clinical features. However, genetic and other clinical findings suggest that these clinical syndromes may be better classified as PR3-positive AAV (PR3-AAV), MPO-positive AAV (MPO-AAV) and, for EGPA, by the presence or absence of ANCA (ANCA+ or ANCA–, respectively). Although any tissue can be involved in AAV, the upper and lower respiratory tract and kidneys are most commonly and severely affected. AAVs have a complex and unique pathogenesis, with evidence for a loss of tolerance to neutrophil proteins, which leads to ANCA-mediated neutrophil activation, recruitment and injury, with effector T cells also involved. Without therapy, prognosis is poor but treatments, typically immunosuppressants, have improved survival, albeit with considerable morbidity from glucocorticoids and other immunosuppressive medications. Current challenges include improving the measures of disease activity and risk of relapse, uncertainty about optimal therapy duration and a need for targeted therapies with fewer adverse effects. Meeting these challenges requires a more detailed knowledge of the fundamental biology of AAV as well as cooperative international research and clinical trials with meaningful input from patients. The anti-neutrophil cytoplasmic antibody-associated vasculitides (AAVs) are autoimmune disorders characterized by inflammation and destruction of small blood vessels. In this Primer, the authors discuss the classification of AAVs and the pathogenetic mechanisms, diagnosis and treatment of these debilitating conditions." @default.
• W137802152 created "2016-06-24" @default.
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• W137802152 date "2020-08-27" @default.
• W137802152 modified "2023-10-14" @default.
• W137802152 title "ANCA-associated vasculitis" @default.
• W137802152 cites W1509116850 @default.
• W137802152 cites W1517672737 @default.
• W137802152 cites W1517801283 @default.
• W137802152 cites W1595642508 @default.
• W137802152 cites W1683214757 @default.
• W137802152 cites W1691880693 @default.
• W137802152 cites W1720230696 @default.
• W137802152 cites W1783939111 @default.
• W137802152 cites W1865491764 @default.
• W137802152 cites W1958558962 @default.
• W137802152 cites W1967599448 @default.
• W137802152 cites W1968465937 @default.
• W137802152 cites W1968598953 @default.
• W137802152 cites W1968834797 @default.
• W137802152 cites W1972218512 @default.
• W137802152 cites W1975394575 @default.
• W137802152 cites W1975466495 @default.
• W137802152 cites W1977715443 @default.
• W137802152 cites W1979398789 @default.
• W137802152 cites W1979530683 @default.
• W137802152 cites W1980066489 @default.
• W137802152 cites W1981535363 @default.
• W137802152 cites W1981778251 @default.
• W137802152 cites W1982658870 @default.
• W137802152 cites W1983585840 @default.
• W137802152 cites W1988635988 @default.
• W137802152 cites W1989583983 @default.
• W137802152 cites W1993041716 @default.
• W137802152 cites W1994239942 @default.
• W137802152 cites W2001403014 @default.
• W137802152 cites W2003875810 @default.
• W137802152 cites W2006413146 @default.
• W137802152 cites W2006765980 @default.
• W137802152 cites W2007669811 @default.
• W137802152 cites W2008930833 @default.
• W137802152 cites W2009150197 @default.
• W137802152 cites W2015836326 @default.
• W137802152 cites W2016547132 @default.
• W137802152 cites W2017731823 @default.
• W137802152 cites W2017942572 @default.
• W137802152 cites W2018293367 @default.
• W137802152 cites W2019173109 @default.
• W137802152 cites W2019274057 @default.
• W137802152 cites W2019873845 @default.
• W137802152 cites W2019960015 @default.
• W137802152 cites W2020736942 @default.
• W137802152 cites W2023134552 @default.
• W137802152 cites W2024564671 @default.
• W137802152 cites W2030598988 @default.
• W137802152 cites W2031517139 @default.
• W137802152 cites W2036292718 @default.
• W137802152 cites W2041565487 @default.
• W137802152 cites W2042103540 @default.
• W137802152 cites W2043436124 @default.
• W137802152 cites W2043756611 @default.
• W137802152 cites W2043940516 @default.
• W137802152 cites W2049483863 @default.
• W137802152 cites W2050962284 @default.
• W137802152 cites W2053251763 @default.
• W137802152 cites W2055896786 @default.
• W137802152 cites W2059475454 @default.
• W137802152 cites W2060098353 @default.
• W137802152 cites W2062735902 @default.
• W137802152 cites W2063340779 @default.
• W137802152 cites W2063731640 @default.
• W137802152 cites W2065201625 @default.
• W137802152 cites W2066508253 @default.
• W137802152 cites W2070469043 @default.
• W137802152 cites W2071333258 @default.
• W137802152 cites W2071985067 @default.
• W137802152 cites W2072998173 @default.
• W137802152 cites W2074402338 @default.
• W137802152 cites W2076527880 @default.
• W137802152 cites W2076736046 @default.
• W137802152 cites W2078785593 @default.
• W137802152 cites W2081654269 @default.
• W137802152 cites W2082874877 @default.
• W137802152 cites W2084056567 @default.
• W137802152 cites W2084287858 @default.
• W137802152 cites W2088445720 @default.
• W137802152 cites W2092644774 @default.
• W137802152 cites W2097446240 @default.
• W137802152 cites W2098062273 @default.

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