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- W137887953 endingPage "359" @default.
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- W137887953 abstract "The breakdown of cartilage and bone in the arthritides prevents the joints from functioning normally. In severe cases, a large proportion of the cartilage that lines the articular surface as well as the underlying bone can be destroyed. The primary cause of cartilage and bone destruction in the arthritides involves the elevated levels of active proteinases degrading the collagen and proteoglycan. In osteoarthritis (OA), there are often very few inflammatory cells during the initial stages of the disease; therefore, the proteinases produced by chondrocytes are likely to play a major role. In contrast, there are many cell types present in a highly inflamed rheumatoid joint, and although proteinases are produced by chondrocytes, other cells such as synovial cells and inflammatory cells produce proteinases and mediators which also play a part in the destruction. This chapter describes the role of proteinases and their inhibitors found in the arthritic joint and their participation in the destruction of collagen and proteoglycan from joint tissues. It may be necessary to combine proteinase inhibitors, either in sequence or with other agents that hit other specific steps in the pathogenesis, before the chronic cycle of joint destruction found in these diseases can be broken." @default.
- W137887953 created "2016-06-24" @default.
- W137887953 creator A5023005098 @default.
- W137887953 date "1995-01-01" @default.
- W137887953 modified "2023-09-26" @default.
- W137887953 title "Proteinases and Connective Tissue Breakdown" @default.
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