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- W137977908 abstract "Over the past 20 years, considerable progress has been made in understanding the etiology of childhood ‘attention deficit hyperactivity disorder’ (ADHD), largely due to the publication of numerous twin studies which are consistent in suggesting substantial genetic influences (i.e., heritabilities ranging from 60% to 90%), nonshared environmental influences that are small-to-moderate in magnitude (i.e., ranging from 10% to 40%), and little-to-no shared environmental influences. Following from these quantitative genetic findings, numerous molecular genetic studies of association and linkage between ADHD and a variety of candidate genes have been conducted since the mid-1990s. The majority of the candidate genes studied underlie various facets of the dopamine, norepinephrine, and serotonin neurotransmitter systems, although the etiological role of candidate genes outside of neurotransmitter systems (e.g., involved in various aspects of brain and nervous system development) also have been examined. This article summarizes recent findings from candidate gene studies of childhood ADHD and highlights those candidate genes for which associations are most replicable and which thus appear most promising. The article concludes with a consideration of some of the emerging themes that will be important in future studies of the genetics of ADHD." @default.
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- W137977908 date "2008-01-01" @default.
- W137977908 modified "2023-09-25" @default.
- W137977908 title "ADHD: Genetic Influences" @default.
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- W137977908 doi "https://doi.org/10.1016/b978-012370877-9.00003-7" @default.
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