Matches in SemOpenAlex for { <https://semopenalex.org/work/W137991795> ?p ?o ?g. }
Showing items 1 to 88 of
88
with 100 items per page.
- W137991795 endingPage "107" @default.
- W137991795 startingPage "99" @default.
- W137991795 abstract "A series of peptidic boronic acids that inhibit the activity of the proteasome were screened by the NCI for activity against a panel of 60 human tumor cell lines. Comparison to data from approx 80,000 other compounds demonstrated that these proteasome inhibitors exhibited a novel pattern of growth inhibition against these cell lines. The potency of these compounds in the cell line screen correlated well with activity against purified proteasomes, indicating that proteasome inhibition was likely causing the growth inhibition. Comparison of bortezomib (formerly known as PS-341) sensitivity to expression levels of thousand of molecular targets within the 60 cell line panel did not yield strong correlations with any single molecular target, consistent with the role of the proteasome in degradation of a multitude of proteins.Key WordsProteasomeNCI COMPAREcorrelationmolecular target" @default.
- W137991795 created "2016-06-24" @default.
- W137991795 creator A5049975653 @default.
- W137991795 creator A5082507805 @default.
- W137991795 date "2004-01-01" @default.
- W137991795 modified "2023-09-23" @default.
- W137991795 title "The Proteasome and the COMPARE Algorithm" @default.
- W137991795 cites W1508295985 @default.
- W137991795 cites W1935443268 @default.
- W137991795 cites W1989076816 @default.
- W137991795 cites W1990183651 @default.
- W137991795 cites W2011420746 @default.
- W137991795 cites W2018498647 @default.
- W137991795 cites W2018843280 @default.
- W137991795 cites W2022537657 @default.
- W137991795 cites W2026825995 @default.
- W137991795 cites W2031317609 @default.
- W137991795 cites W2055008923 @default.
- W137991795 cites W2067634043 @default.
- W137991795 cites W2082140471 @default.
- W137991795 cites W2088298846 @default.
- W137991795 cites W2090003571 @default.
- W137991795 cites W2097072725 @default.
- W137991795 cites W2098426299 @default.
- W137991795 cites W2126653080 @default.
- W137991795 cites W2136470788 @default.
- W137991795 cites W2155208683 @default.
- W137991795 cites W2319307754 @default.
- W137991795 doi "https://doi.org/10.1007/978-1-59259-794-9_8" @default.
- W137991795 hasPublicationYear "2004" @default.
- W137991795 type Work @default.
- W137991795 sameAs 137991795 @default.
- W137991795 citedByCount "3" @default.
- W137991795 countsByYear W1379917952014 @default.
- W137991795 crossrefType "book-chapter" @default.
- W137991795 hasAuthorship W137991795A5049975653 @default.
- W137991795 hasAuthorship W137991795A5082507805 @default.
- W137991795 hasConcept C104317684 @default.
- W137991795 hasConcept C185592680 @default.
- W137991795 hasConcept C202751555 @default.
- W137991795 hasConcept C203014093 @default.
- W137991795 hasConcept C25602115 @default.
- W137991795 hasConcept C27740335 @default.
- W137991795 hasConcept C2776364478 @default.
- W137991795 hasConcept C2777478702 @default.
- W137991795 hasConcept C2778367456 @default.
- W137991795 hasConcept C2779707156 @default.
- W137991795 hasConcept C54355233 @default.
- W137991795 hasConcept C55493867 @default.
- W137991795 hasConcept C57992300 @default.
- W137991795 hasConcept C62112901 @default.
- W137991795 hasConcept C81885089 @default.
- W137991795 hasConcept C86803240 @default.
- W137991795 hasConceptScore W137991795C104317684 @default.
- W137991795 hasConceptScore W137991795C185592680 @default.
- W137991795 hasConceptScore W137991795C202751555 @default.
- W137991795 hasConceptScore W137991795C203014093 @default.
- W137991795 hasConceptScore W137991795C25602115 @default.
- W137991795 hasConceptScore W137991795C27740335 @default.
- W137991795 hasConceptScore W137991795C2776364478 @default.
- W137991795 hasConceptScore W137991795C2777478702 @default.
- W137991795 hasConceptScore W137991795C2778367456 @default.
- W137991795 hasConceptScore W137991795C2779707156 @default.
- W137991795 hasConceptScore W137991795C54355233 @default.
- W137991795 hasConceptScore W137991795C55493867 @default.
- W137991795 hasConceptScore W137991795C57992300 @default.
- W137991795 hasConceptScore W137991795C62112901 @default.
- W137991795 hasConceptScore W137991795C81885089 @default.
- W137991795 hasConceptScore W137991795C86803240 @default.
- W137991795 hasLocation W1379917951 @default.
- W137991795 hasOpenAccess W137991795 @default.
- W137991795 hasPrimaryLocation W1379917951 @default.
- W137991795 hasRelatedWork W2031286395 @default.
- W137991795 hasRelatedWork W2049399172 @default.
- W137991795 hasRelatedWork W2050290922 @default.
- W137991795 hasRelatedWork W2151526425 @default.
- W137991795 hasRelatedWork W2162023777 @default.
- W137991795 hasRelatedWork W2385905373 @default.
- W137991795 hasRelatedWork W2387414814 @default.
- W137991795 hasRelatedWork W2524983907 @default.
- W137991795 hasRelatedWork W3156448547 @default.
- W137991795 hasRelatedWork W3156535202 @default.
- W137991795 isParatext "false" @default.
- W137991795 isRetracted "false" @default.
- W137991795 magId "137991795" @default.
- W137991795 workType "book-chapter" @default.