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- W137998119 abstract "Glucocorticoids secreted in response to stress activation of the hypothalamic-pituitary-adrenal axis feed back onto the hypothalamus to rapidly suppress neuroendocrine activation, including oxytocin and vasopressin secretion. Here we provide a brief review focused on our recent findings of a rapid glucocorticoid-induced opposing regulation of glutamate and gamma-aminobutyric acid (GABA) inputs to magnocellular neurons via the release of distinct retrograde messengers. The stress hormone corticosterone and its synthetic analogue dexamethasone elicit the rapid retrograde release of endocannabinoids by activating a novel membrane-associated, G protein-coupled receptor in parvocellular and magnocellular neuroendocrine cells of the hypothalamic paraventricular and supraoptic nuclei. Glucocorticoids also cause the rapid retrograde release of an unknown messenger that facilitates presynaptic GABA release onto magnocellular neuroendocrine cells. These finding suggest that there is a strict synapse-specific segregation of the opposing actions of the two retrogradely released messengers. Thus, the combined actions of glucocorticoids cause a rapid synaptic inhibition of the magnocellular neurons and would be expected, therefore, to mediate a rapid feedback inhibition of the secretion of oxytocin and vasopressin during stress activation of the hypothalamic-pituitary-adrenal axis." @default.
- W137998119 created "2016-06-24" @default.
- W137998119 creator A5021583015 @default.
- W137998119 creator A5037845007 @default.
- W137998119 date "2008-01-01" @default.
- W137998119 modified "2023-09-27" @default.
- W137998119 title "Rapid synapse-specific regulation of hypothalamic magnocellular neurons by glucocorticoids" @default.
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- W137998119 doi "https://doi.org/10.1016/s0079-6123(08)00431-7" @default.
- W137998119 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/18655897" @default.
- W137998119 hasPublicationYear "2008" @default.
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